Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease
dc.contributor.author | Gardenal, Emanuela | |
dc.contributor.author | Chiarini, Anna | |
dc.contributor.author | Armato, Ubaldo | |
dc.contributor.author | Dal Prà, Ilaria | |
dc.contributor.author | Verkhratsky, Alexei | |
dc.contributor.author | Rodríguez Arellano, José Julio | |
dc.date.accessioned | 2017-05-08T09:12:26Z | |
dc.date.available | 2017-05-08T09:12:26Z | |
dc.date.issued | 2017-02-16 | |
dc.identifier.citation | Frontiers in Neuroscience 11 : (2017) // Article ID 81 | es_ES |
dc.identifier.issn | 1662-453X | |
dc.identifier.uri | http://hdl.handle.net/10810/21485 | |
dc.description.abstract | The Calcium-Sensing Receptor (CaSR) is a G-protein coupled, 7-transmembrane domain receptor ubiquitously expressed throughout the body, brain including. The role of CaSR in the CNS is not well understood; its expression is increasing during development, which has been implicated in memory formation and consolidation, and CaSR localization in nerve terminals has been related to synaptic plasticity and neurotransmission. There is an emerging evidence of CaSR involvement in neurodegenerative disorders and Alzheimer's disease (AD) in particular, where the over-production of beta-amyloid peptides was reported to activate CaSR. In the present study, we performed CaSR immunohistochemical and densitometry analysis in the triple transgenic mouse model of AD (3xTg-AD). We found an increase in the expression of CaSR in hippocampal CA1 area and in dentate gyrus in the 3xTg-AD mice when compared to non-transgenic control animals. This increase was significant at 9 months of age and further increased at 12 and 18 months of age. This increase paralleled the accumulation of beta-amyloid plaques with age. Increased expression of CaSR favors beta-amyloidogenic pathway following direct interactions between beta-amyloid and CaSR and hence may contribute to the pathological evolution of the AD. In the framework of this paradigm CaSR may represent a novel therapeutic target. | es_ES |
dc.description.sponsorship | We thank Dr Fatima Zallo Diaz, for her help and assistance with the figures. Authors research was supported by Alzheimer's Research Trust (UK) Programme Grant [grant number ART/PG2004A/1 (to AV and JR)]; by the Grant Agency of the Czech Republic [grant number GACR 309/09/1696 (to JR); GACR 305/08/1381 and GACR 305/08/1384 (to AV)] as well as by the Spanish Government Plan Nacional de I+D+I 2008-2011, and ISCIII Subdireccion General de Evaluacion y Fomento de la investigacion co-financed by FEDER [grant number PI10/02738 (to JR and AV)]. The Government of the Basque Country [grant number AE-2010-1-28; AEGV10/16, GV2011111020 (to JR)]; as well as by the Spanish Ministerio de Economia y Competitividad, RETOS Colaboracion [grant number RTC-2015-3542-1 co-financed by FEDER (to JR)] and by the Ministry of Italian University and Research (MIUR) to EG, AC, UA, and ID. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RTC2015-3542-1 | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Alzheimer's disease | es_ES |
dc.subject | beta-amyloid | es_ES |
dc.subject | tau | es_ES |
dc.subject | calcium sensing receptor (CaSR) | es_ES |
dc.subject | hippocampus KeyWords Plus | es_ES |
dc.subject | outward K+ chanel | es_ES |
dc.subject | human cerebral astrocytes | es_ES |
dc.subject | adult human astrocytes | es_ES |
dc.subject | proinflammatory cytokines | es_ES |
dc.subject | plaque-formation | es_ES |
dc.subject | nerve-terminals | es_ES |
dc.subject | dentate gyrus | es_ES |
dc.subject | expression | es_ES |
dc.subject | neurons | es_ES |
dc.subject | beta | es_ES |
dc.title | Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2017 Gardenal, Chiarini, Armato, Dal Prà, Verkhratsky and Rodríguez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Frontiers | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | http://journal.frontiersin.org/article/10.3389/fnins.2017.00081/full | es_ES |
dc.identifier.doi | 10.3389/fnins.2017.00081 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
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