Functional Inhibitory Control Dynamics in Impulse Control Disorders in Parkinson’s Disease
Fecha
2020Autor
Paz-Alonso, Pedro M.
Navalpotro-Gomez, I.
Boddy, P.
Dacosta-Aguayo, R.
Delgado-Alvarado, M.
Quiroga-Varela, Ana
Jimenez-Urbieta, H.
Carreiras, Manuel
Rodriguez-Oroz, Maria C.
Metadatos
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Paz‐Alonso, P.M., Navalpotro‐Gomez, I., Boddy, P., Dacosta‐Aguayo, R., Delgado‐Alvarado, M., Quiroga‐Varela, A., Jimenez‐Urbieta, H., Carreiras, M. and Rodriguez‐Oroz, M.C. (2020), Functional inhibitory control dynamics in impulse control disorders in Parkinson's disease. Mov Disord, 35: 316-325. doi:10.1002/mds.27885
Resumen
ABSTRACT: Background: Impulse control disorders
related to alterations in the mesocorticolimbic dopamine
network occur in Parkinson’s disease (PD). Our objective
was to investigate the functional neural substrates of
reward processing and inhibitory control in these patients.
Methods: Eighteen PD patients with impulse control disorders,
17 without this complication, and 18 healthy controls
performed a version of the Iowa Gambling Task
during functional magnetic resonance scanning under
3 conditions: positive, negative, and mixed feedback.
Whole-brain contrasts, regions of interest, time courses,
functional connectivity analyses, and brain-behavior
associations were examined.
Results: PD patients with impulse control disorders
exhibited hyperactivation in subcortical and cortical regions
typically associated with reward processing and inhibitory
control compared with their PD and healthy control counterparts.
Time-course analyses revealed that only PD
patients with impulse control disorders exhibited stronger
signal intensity during the initial versus final periods of the
negative-feedback condition in bilateral insula, and right
ventral striatum. Interestingly, hyperactivation of all the
examined right-lateralized frontostriatal areas during negative
feedback was positively associated with impulse control
disorder severity. Importantly, positive associations
between impulse control disorder severity and regional
activations in the right insula and right inferior frontal gyrus,
but not the right subthalamic nucleus, were mediated by
functional connectivity with the right ventral striatum.
Conclusions: During a reward-based task, PD patients
with impulse control disorders showed hyperactivation
in a right-lateralized network of regions including the
subthalamic nucleus that was strongly associated with
impulse control disorder severity. In these patients, the
right ventral striatum in particular played a critical role in
modulating the functional dynamics of right-lateralized
inhibitory-control frontal regions when facing penalties.