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dc.contributor.authorGómez Zorita, Saioa
dc.contributor.authorGonzález Arceo, Maitane
dc.contributor.authorTrepiana Arin, Jenifer ORCID
dc.contributor.authorAguirre López, Leixuri ORCID
dc.contributor.authorCrujeiras, Ana B.
dc.contributor.authorIrles, Esperanza
dc.contributor.authorSegues, Nerea
dc.contributor.authorBujanda Fernández de Pierola, Luis ORCID
dc.contributor.authorPortillo Baquedano, María Puy ORCID
dc.date.accessioned2020-11-30T10:09:10Z
dc.date.available2020-11-30T10:09:10Z
dc.date.issued2020-10-24
dc.identifier.citationAntioxidants 9(11) : (2020) // Article ID 1042es_ES
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10810/48709
dc.description.abstractDifferent studies have revealed that oxidative stress and inflammation are crucial in NAFLD (Non-alcoholic fatty liver disease). The aim of this study is to analyze whether pterostilbene and resveratrol are able to either avoid or delay the progression of non-alcoholic liver steatosis towards steatohepatitis. This has been performed by examining their effects on oxidative stress, inflammation, fibrosis and pre-carcinogenic stages. Rats were distributed into five experimental groups and were fed with either a standard diet or a high-fat high-fructose diet, supplemented or not with pterostilbene (15 or 30 mg/kg/d) or resveratrol (30 mg/kg/d), for 8 weeks. Liver histological analysis was carried out by haematoxylin–eosin staining. Serum and hepatic oxidative stress-related parameters were assessed using spectrophotometry, and the expression of genes related to inflammation, fibrosis and cancer by qRT-PCR. The dietary model used in this study led to the development of steatohepatitis, where rats displayed oxidative stress, inflammation and ballooning, although not fibrosis. It also modified the expression of hepatocarcinoma-related genes. The results show, for the first time, that pterostilbene was able to partially prevent these alterations, with the exception of changes in hepatocarcinoma-related genes, mainly at 30 mg/kg/d. Pterostilbene was more effective than its parent compound resveratrol, probably due to its high bioavailability and higher anti-oxidant and anti-inflammatory activities, attributable to its different chemical structure.es_ES
dc.description.sponsorshipThis study was supported by grants from the Ministerio de Economía y Competitividad (AGL-2015-65719-R), Fondo Europeo de Desarrollo Regional (FEDER), the Instituto de Salud Carlos III (CIBERobn) under Grant CB12/03/30007 and the University of the Basque Country under Grant GIU18-173.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/AGL-2015-65719-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectpterostilbenees_ES
dc.subjectresveratroles_ES
dc.subject(poly)phenolses_ES
dc.subjectliver steatosises_ES
dc.subjectliver steatohepatitises_ES
dc.subjecthepatocarcinomaes_ES
dc.subjectoxidative stresses_ES
dc.subjectinflammationes_ES
dc.subjectrates_ES
dc.titleComparative Effects of Pterostilbene and Its Parent Compound Resveratrol on Oxidative Stress and Inflammation in Steatohepatitis Induced by High-Fat High-Fructose Feedinges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2020-11-26T14:08:07Z
dc.rights.holder2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/9/11/1042/htmes_ES
dc.identifier.doi10.3390/antiox9111042
dc.departamentoesFarmacia y ciencias de los alimentos
dc.departamentoeuFarmazia eta elikagaien zientziak


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2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).