Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways
dc.contributor.author | Preman, Pranav | |
dc.contributor.author | Alfonso Triguero, Maria | |
dc.contributor.author | Alberdi Alfonso, Elena María | |
dc.contributor.author | Verkhratsky, Alexei | |
dc.contributor.author | Arranz Mendiguren, Amaia | |
dc.date.accessioned | 2021-03-30T11:23:48Z | |
dc.date.available | 2021-03-30T11:23:48Z | |
dc.date.issued | 2021-03-04 | |
dc.identifier.citation | Cells 10(3) : (2021) // Article ID 540 | es_ES |
dc.identifier.issn | 2073-4409 | |
dc.identifier.uri | http://hdl.handle.net/10810/50827 | |
dc.description.abstract | Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. Recent data provide compelling evidence that distinct astrocyte states are associated with specific stages of Alzheimer´s disease. The advent of transcriptomics technologies enables rapid progress in the characterisation of such pathological astrocyte states. In this review, we provide an overview of the origin, main functions, molecular and morphological features of astrocytes in physiological as well as pathological conditions related to Alzheimer´s disease. We will also explore the main roles of astrocytes in the pathogenesis of Alzheimer´s disease and summarize main transcriptional changes and altered molecular pathways observed in astrocytes during the course of the disease. | es_ES |
dc.description.sponsorship | This work was supported by the FEDER/Ministerio de Ciencia e Innovación—Agencia Estatal de Investigación grant RTI2018-101850-A-I00 to A.M.A. (Spain), and a start-up grant from the IKERBASQUE Basque Foundation of Science to A.M.A. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/RTI2018-101850-A-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | astrocyte | es_ES |
dc.subject | Alzheimer´s disease | es_ES |
dc.subject | neurodegeneration | es_ES |
dc.subject | transcriptomics | es_ES |
dc.subject | RNA sequencing (RNA-seq) | es_ES |
dc.subject | cellular states | es_ES |
dc.title | Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-03-26T14:06:53Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4409/10/3/540/htm | es_ES |
dc.identifier.doi | 10.3390/cells10030540 | |
dc.departamentoes | Neurociencias | |
dc.departamentoeu | Neurozientziak |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).