A novel double-hit animal model of schizophrenia: behavioural assessment in male and female mice
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2020-11-17Autor
Ortega Calvo, Jorge
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European Neuropsychopharmacology 40(Sup1) :S53-S54 (2020)
Resumen
Background: A growing body of evidence support that maternal prenatal infections represent a risk factor for schizophrenia in offspring. Moreover, stressful events during critical neurodevelopmental periods, such as adolescence, may trigger the onset of the disease in predisposed individuals. Thus, a prenatal priming event (i.e. maternal infection during pregnancy) that would induce vulnerability, followed by a second stressful hit in peripuberty may lead to the onset of schizophrenia