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Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration
dc.contributor.author | Arrazola Sastre, Alazne | |
dc.contributor.author | Luque Montoro, Miriam | |
dc.contributor.author | Lacerda, Hadriano M. | |
dc.contributor.author | Llavero Bernal, Francisco | |
dc.contributor.author | Zugaza Gurruchaga, José Luis | |
dc.date.accessioned | 2021-05-17T10:41:54Z | |
dc.date.available | 2021-05-17T10:41:54Z | |
dc.date.issued | 2021-04-23 | |
dc.identifier.citation | International Journal of Molecular Sciences 22(9) : (2021) // Article ID 4425 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10810/51413 | |
dc.description.abstract | Small guanosine triphosphatases (GTPases) of the Rab and Arf families are key regulators of vesicle formation and membrane trafficking. Membrane transport plays an important role in the central nervous system. In this regard, neurons require a constant flow of membranes for the correct distribution of receptors, for the precise composition of proteins and organelles in dendrites and axons, for the continuous exocytosis/endocytosis of synaptic vesicles and for the elimination of dysfunctional proteins. Thus, it is not surprising that Rab and Arf GTPases have been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Both pathologies share characteristics such as the presence of protein aggregates and/or the fragmentation of the Golgi apparatus, hallmarks that have been related to both Rab and Arf GTPases functions. Despite their relationship with neurodegenerative disorders, very few studies have focused on the role of these GTPases in the pathogenesis of neurodegeneration. In this review, we summarize their importance in the onset and progression of Alzheimer’s and Parkinson’s diseases, as well as their emergence as potential therapeutical targets for neurodegeneration. | es_ES |
dc.description.sponsorship | A.A.S. is a recipient of a predoctoral fellowship (PRE_2017_1_0016) from the Basque Government. M.L.M. is a recipient of a fellowship from Foundation “Jesús de Gangoiti y Barrera”. J.L.Z. was supported by the Instituto de Salud Carlos III (PI18/00207) and the University of Basque Country Grant (US19/04). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | Rab GTPase | es_ES |
dc.subject | Arf GTPase | es_ES |
dc.subject | small GTPase | es_ES |
dc.subject | Alzheimer | es_ES |
dc.subject | Parkinson | es_ES |
dc.subject | neurodegeneration | es_ES |
dc.subject | membrane trafficking | es_ES |
dc.subject | vesicle | es_ES |
dc.subject | transport | es_ES |
dc.title | Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-05-13T14:32:21Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/22/9/4425/htm | es_ES |
dc.identifier.doi | 10.3390/ijms22094425 | |
dc.departamentoes | Genética, antropología física y fisiología animal | |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia |
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Excepto si se señala otra cosa, la licencia del ítem se describe como 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).