Reducing Passive Drug Diffusion from Electrophoretic DrugDelivery Devices through Co-Ion Engineering
dc.contributor.author | Chen, Shao-Tuan | |
dc.contributor.author | Renny, Megan N. | |
dc.contributor.author | Tomé, Liliana C. | |
dc.contributor.author | Olmedo Martínez, Jorge L. | |
dc.contributor.author | Udabe Sánchez, Esther | |
dc.contributor.author | Jenkins, Elise P. W. | |
dc.contributor.author | Mecerreyes Molero, David | |
dc.contributor.author | Malliaras, George G. | |
dc.contributor.author | McLeod, Robert R. | |
dc.contributor.author | Proctor, Christopher M. | |
dc.date.accessioned | 2022-01-07T11:00:14Z | |
dc.date.available | 2022-01-07T11:00:14Z | |
dc.date.issued | 2021-06 | |
dc.identifier.citation | Advanced Science 8(12) : (2021) // Article ID 2003995 | es_ES |
dc.identifier.issn | 2198-3844 | |
dc.identifier.uri | http://hdl.handle.net/10810/54832 | |
dc.description.abstract | Implantable electrophoretic drug delivery devices have shown promise for applications ranging from treating pathologies such as epilepsy and cancer to regulating plant physiology. Upon applying a voltage, the devices electrophoretically transport charged drug molecules across an ion-conducting membrane out to the local implanted area. This solvent-flow-free "dry" delivery enables controlled drug release with minimal pressure increase at the outlet. However, a major challenge these devices face is limiting drug leakage in their idle state. Here, a method of reducing passive drug leakage through the choice of the drug co-ion is presented. By switching acetylcholine's associated co-ion from chloride to carboxylate co-ions as well as sulfopropyl acrylate-based polyanions, steady-state drug leakage rate is reduced up to sevenfold with minimal effect on the active drug delivery rate. Numerical simulations further illustrate the potential of this method and offer guidance for new material systems to suppress passive drug leakage in electrophoretic drug delivery devices. | es_ES |
dc.description.sponsorship | S.-T.C. and M.N.R. contributed equally to this work. S.-T.C. acknowledges funding from the Cambridge Trust and Ministry of Education, Taiwan. C.M.P. acknowledges funding from the University of Cambridge Borysiewicz Fellowship program as well as the Biotechnology and Biological Sciences Research Council David Phillips Fellowship. L.C.T. has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 745734. E.U. thanks the Spanish MINECO for her FPU fellowship, while JLOM acknowledges the National Council of Science and Technology (CONACYT) in Mexico for his grant 471837. This work was supported by Marie Sklodowska-Curie Research and Innovation Staff Exchanges (RISE) project under the grant agreement no. 823989 "IONBIKE." M.N.R. acknowledges support from the National Science Foundation grant NSF EMPD 1509909 and NSF Plant Genome Research Project, Special Initiatives grant 1935594. E.P.W.J. acknowledges funding by a Trinity Hall Research Studentship. The authors acknowledge funding from EPSRC (EP/S009000/1). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/745734 | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/823989 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | bioelectronics | es_ES |
dc.subject | device optimization | es_ES |
dc.subject | electrophoretic transport | es_ES |
dc.subject | targeted drug delivery | es_ES |
dc.title | Reducing Passive Drug Diffusion from Electrophoretic DrugDelivery Devices through Co-Ion Engineering | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.This is an open access article under the terms of the Creative CommonsAttribution License, which permits use, distribution and reproduction inany medium, provided the original work is properly cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/advs.202003995 | es_ES |
dc.identifier.doi | 10.1002/advs.202003995 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Polímeros y Materiales Avanzados: Física, Química y Tecnología | es_ES |
dc.departamentoeu | Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia | es_ES |
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Except where otherwise noted, this item's license is described as 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.This is an open access article under the terms of the Creative CommonsAttribution License, which permits use, distribution and reproduction inany medium, provided the original work is properly cited.