Kinetic Resolution in Transannular Morita-Baylis-Hillman Reaction: An Approximation to the Synthesis of Sesquiterpenes from Guaiane Family

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Date
2022-01-08
Author
Mato Santamaría, Raquel
Manzano, Rubén ORCID
Reyes Martín, Efraim
Prieto Aretxabaleta, Liher ORCID
Uria Pujana, Uxue ORCID
Carrillo Fernández, María Luisa ORCID
Vicario Hernando, José Luis ORCID
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Catalysts 12(1) : (2022) // Article ID 67
URI
http://hdl.handle.net/10810/55089
Abstract
An approximation to the synthesis of several sesquiterpenes from the Guaiane family is described in which the core structure was obtained through a transannular Morita-Baylis-Hillman reaction performed under kinetic resolution. Several manipulations of the obtained MBH adduct have been carried out directed towards the total synthesis of &gamma;-Gurjunene, to the formal synthesis of Clavukerin A, to the synthesis of a non-natural isomer of <i>isoguaiane</i> and to the synthesis of an advanced intermediate in the total synthesis of Palustrol.
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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).