Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
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2022-10Autor
Navarro Romero, Alba
Galera López, Lorena
Ortíz Romero, Paula
Llorente Ovejero, Alberto
de los Reyes Ramírez, Lucía
Bengoetxea de Tena, Iker
García Elías, Anna
Mas-Stachurska, Aleksandra
Reixachs Solé, Marina
Pastor, Antoni
De la Torre, Rafael
Maldonado, Rafael
Benito, Begoña
Eyras, Eduardo
Campuzano, Victoria
Ozaita, Andres
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eLife 11 : (2022) // Article ID e72560
Resumen
Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular abnormalities. Nowadays, there are no pharmacological treatments to directly ameliorate the main traits of WBS. The endocannabinoid system (ECS), given its relevance for both cognitive and cardiovascular function, could be a potential druggable target in this syndrome. We analyzed the components of the ECS in the complete deletion (CD) mouse model of WBS and assessed the impact of its pharmacological modulation in key phenotypes relevant for WBS. CD mice showed the characteristic hypersociable phenotype with no preference for social novelty and poor short-term object-recognition performance. Brain cannabinoid type-1 receptor (CB1R) in CD male mice showed alterations in density and coupling with no detectable change in main endocannabinoids. Endocannabinoid signaling modulation with subchronic (10 days) JZL184, a selective inhibitor of monoacylglycerol lipase, specifically normalized the social and cognitive phenotype of CD mice. Notably, JZL184 treatment improved cardiovascular function and restored gene expression patterns in cardiac tissue. These results reveal the modulation of the ECS as a promising novel therapeutic approach to improve key phenotypic alterations in WBS.
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