Biomimetic Tweezers for N-Glycans: Selective Recognition of the Core GlcNAc(2) Disaccharide of the Sialylglycopeptide SGP
dc.contributor.author | Milanesi, Francesco | |
dc.contributor.author | Unione, Luca | |
dc.contributor.author | Arda, Ana | |
dc.contributor.author | Nativi, Cristina | |
dc.contributor.author | Jiménez Barbero, Jesús | |
dc.contributor.author | Roelens, Stefano | |
dc.contributor.author | Francesconi, Oscar | |
dc.date.accessioned | 2023-05-09T14:42:05Z | |
dc.date.available | 2023-05-09T14:42:05Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | Chemistry - A European Journal 29(18) : (2023) // Article ID e202203591 | es_ES |
dc.identifier.issn | 0947-6539 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.uri | http://hdl.handle.net/10810/61055 | |
dc.description.abstract | In recent years, glycomics have shown how pervasive the role of carbohydrates in biological systems is and how chemical tools are essential to investigate glycan function and modulate carbohydrate-mediated processes. Biomimetic receptors for carbohydrates can carry out this task but, although significant affinities and selectivities toward simple saccharides have been achieved, targeting complex glycoconjugates remains a goal yet unattained. In this work we report the unprecedented recognition of a complex biantennary sialylglycopeptide (SGP) by a tweezers-shaped biomimetic receptor, which selectively binds to the core GlcNAc2 disaccharide of the N-glycan with an affinity of 170 μM. Because of the simple structure and the remarkable binding ability, this biomimetic receptor can represent a versatile tool for glycoscience, opening the way to useful applications. | es_ES |
dc.description.sponsorship | We thank MIUR-Italy “Progetto Dipartimenti di Eccellenza 2018–2022” allocated to Department of Chemistry Ugo Schiff, COST Action (CA18132), MIUR-Italy PRIN2017 (2017XZ2ZBK) for granting a fellowship to F.M. and Ente Cassa di Risparmio di Firenze (Italy) is acknowledged for granting an ITC nanocalorimeter and a high-field NMR spectrometer. Open Access funding provided by Università degli Studi di Firenze within the CRUI-CARE Agreement. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | biomimetic artificial receptors | es_ES |
dc.subject | carbohydrates | es_ES |
dc.subject | chitobiose | es_ES |
dc.subject | glycan | es_ES |
dc.subject | molecular recognition | es_ES |
dc.title | Biomimetic Tweezers for N-Glycans: Selective Recognition of the Core GlcNAc(2) Disaccharide of the Sialylglycopeptide SGP | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202203591 | es_ES |
dc.departamentoes | Química Orgánica e Inorgánica | es_ES |
dc.departamentoeu | Kimika Organikoa eta Ez-Organikoa | es_ES |
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Except where otherwise noted, this item's license is described as © 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.