Intramolecular Addition of Heteroaryllithiums onto Activated Alkenes. Access to Heterofused Indolizines and Pyrroloazepines
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Date
2017-02-23Author
Rebolledo Azcargorta, Ane
Coya Díaz de Sarralde, Estibaliz
Panaite, Ana María
Sotomayor Anduiza, María Nuria
Lete Expósito, María Esther
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European Journal of Organic Chemistry 2017 : 2462-2468 (2017)
Abstract
Heteroaryllithiums, obtained via MesLi mediated halogen- lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron rich (thiophenyl) and electron deficient (pyridinyl, quinolinyl) heteroaromatic halides can be used for the formation of six- and seven membered rings, providing an efficient route to fused indolizines and pyrroloazepines in moderate to good yields.