Intramolecular Addition of Heteroaryllithiums onto Activated Alkenes. Access to Heterofused Indolizines and Pyrroloazepines
Ikusi/ Ireki
Data
2017-02-23Egilea
Rebolledo Azcargorta, Ane
Coya Díaz de Sarralde, Estibaliz
Panaite, Ana María
Sotomayor Anduiza, María Nuria
Lete Expósito, María Esther
European Journal of Organic Chemistry 2017 : 2462-2468 (2017)
Laburpena
Heteroaryllithiums, obtained via MesLi mediated halogen- lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron rich (thiophenyl) and electron deficient (pyridinyl, quinolinyl) heteroaromatic halides can be used for the formation of six- and seven membered rings, providing an efficient route to fused indolizines and pyrroloazepines in moderate to good yields.