Chemerin concentrations in infants born small for gestational age: correlations with triglycerides and parameters related to glucose homeostasis
Fecha
2020-06-16Autor
Léniz Rodríguez, Asier
Del Hoyo Moracho, Marta
Díez López, Ignacio
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Journal of Physiology and Biochemistry 77 : 133-140 (2021)
Resumen
[EN]Infants born small for gestational age (SGA) are known to have increased risk of developing several pathologies, including the
metabolic syndrome, when they grow up. It has been described that both the growth pattern of these children as well as the risk of
their presenting future metabolic disorders can be influenced by the expression of adipokines. Among them, chemerin has demonstrated
to be implicated in lipid and glucose metabolism, presenting higher circulating concentration in diabetic and obese subjects.
Thus, the aim of this study was to analyze the association of anthropometric parameters and plasmatic biochemical parameters with
circulating chemerin concentration in SGA children. This prospective, longitudinal study was carried out in plasma samples of
Caucasian children born SGA at Hospital Universitario de Álava-Txagorritxu. Significant positive correlations were observed
between chemerin concentrations at 3 months and insulin values at 3 months and also with triglyceride levels at 24 months.
These associations weremaintained after adjustment by anthropometric parameters. Therefore, we suggest that circulating chemerin
concentration, measured at an early age, might be an indicator of future metabolic alterations in SGA children.