Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives

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2018-09-15
Autor
Maestro Burzaco, Aitor
Martín Encinas, Endika
Alonso Pérez, Concepción Estibaliz ORCID
Martínez de Marigorta Izaga, Edorta ORCID
Rubiales Alcaine, María Gloria ORCID
Vicario Hernando, Javier ORCID
Palacios Gambra, Francisco Javier ORCID
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European Journal of Medicinal Chemistry 158 : 874-883 (2018)
URI
http://hdl.handle.net/10810/66601
Resumen
An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma).
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