BackExaminar INVESTIGACIÓN por departamento (cas.) "Bioquímica y biología molecular"
Now showing items 21-40 of 428
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Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments
; ; ; Carravilla Palomanes, Pablo
; ; ; Sánchez Eugenia, Rubén ; ; ; ; ; ; ; ; ; ; ; ; (Cell Press, 2020-08-18)
The contribution of membrane interfacial interactions to recognition of membrane-embedded antigens by antibodies is currently unclear. This report demonstrates the optimization of this type of antibodies via chemical ... -
Age, Origin and Functional Study of the Prevalent LDLR Mutation Causing Familial Hypercholesterolaemia in Gran Canaria
(MDPI, 2023-07-11)The p.(Tyr400_Phe402del) mutation in the LDL receptor (LDLR) gene is the most frequent cause of familial hypercholesterolaemia (FH) in Gran Canaria. The aim of this study was to determine the age and origin of this prevalent ... -
Agricultural Soils Amended with Thermally-Dried Anaerobically-Digested Sewage Sludge Showed Increased Risk of Antibiotic Resistance Dissemination
(Frontiers Media, 2021-04-28)The application of sewage sludge (SS) to agricultural soil can help meet crop nutrient requirements and enhance soil properties, while reusing an organic by-product. However, SS can be a source of antibiotic resistance ... -
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif
; ; ; ; ; ; ; ; ; ; ; Shnyrova Zhadan, Anna; (Nature, 2024-01)
The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial and peroxisomal fission, but the regulatory mechanisms remain ambiguous. Here we find that a conserved, intrinsically disordered, six-residue ... -
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
(Nature, 2020-08-20)Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused ... -
An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability
Michelena Sánchez, Jone; Apraiz García, Aintzane ; Vallejo Rodríguez, Jon ; García Santisteban, Iraia ; Fullaondo Elordui-Zapaterieche, Asier ; ; ; Zubiaga Elordieta, Ana María (Oxford University Press, 2018-05-18)
The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ... -
An Epilepsy-Causing Mutation Leads to Co-Translational Misfolding of the Kv7.2 Channel
; ; ; ; ; ; Núñez Viadero, Eider; ; ; ; ; (Springer, 2021-05-21)
BACKGROUND: The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. ... -
Analysis of SUMOylated proteins using SUMO-traps
Da Silva Ferrada, Elisa; Xolalpa, Wendy; Lang, Valerie; Aillet, Fabienne; Martín-Ruiz, Itziar; De la Cruz-Herrera, Carlos F.; Lopitz Otsoa, Fernando; Carracedo Pérez, Arkaitz; Goldenberg, Seth J.; Rivas, Carmen; England, Patrick; Rodríguez, Manuel S. (Nature Publishing Group, 2013-04-22)
SUMO-modified proteins are recognized by SUMO interacting motifs (SIMs), thus triggering diverse cellular responses. Here SIMs were used to develop SUMO-traps to capture endogenous SUMOylated proteins. Our results show ... -
Analysis on the Characterization of Multiphoton Microscopy Images for Malignant Neoplastic Colon Lesion Detection under Deep Learning Methods
Terradillos Fernández, Elena; López Saratxaga, Cristina; Mattana, Sara; Cicchi, Riccardo; Pavone, Francesco S.; Andraka Rueda, Nagore; Glover, Benjamin J.; Arbide del Río, Nagore; Velasco Arteche, Jacques; Etxezarraga Zuluaga, María Carmen; Picón Ruiz, Artzai (Wolters Kluwer, 2021-06-21)
Background: Colorectal cancer has a high incidence rate worldwide, with over 1.8 million new cases and 880,792 deaths in 2018. Fortunately, its early detection significantly increases the survival rate, reaching a cure ... -
Antibiotic Resistance in Agricultural Soil and Crops Associated to the Application of Cow Manure-Derived Amendments from Conventional and Organic Livestock Farms
(Frontiers Media, 2021-02-23)he application of organic amendments to agricultural soil can enhance crop yield, while improving the physicochemical and biological properties of the recipient soils. However, the use of manure-derived amendments as ... -
Antibiotics in Dairy Production: Where Is the Problem?
Virto Lecuona, María Dolores; ; Amores Olazaguirre, Gustavo ; Hernández Ochoa, Igor (MDPI, 2022-08-01)
Antibiotics have long been used for the prevention and treatment of common diseases and for prophylactic purposes in dairy animals. However, in recent decades it has become a matter of concern due to the widespread belief ... -
Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity
Orzáez, Mar; Sancho, Mónica; Marchán, Sandra; Mondragón, Laura; Montava, Rebeca; García Valero, Juan; Landeta Díaz, Olatz; Basáñez Asúa, Gorka; Carbajo, Rodrigo J.; Pineda-Lucena, Antonio; Bujons, Jordi; Moure, Alejandra; Messeguer, Angel; Lagunas, Carmen; Herrero, Carmen; Pérez- Payá, Enrique (Public Library Science, 2014-10-20)
Background: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although ... -
Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
(MDPI, 2019-03-22)Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriers in cancer therapy. SLNs ... -
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
Fernández Ramos, David; Lopitz Otsoa, Fernando; De la Cruz Villar, Laura; Bilbao García, Jon; Pagano, Martina; Mosca, Laura; Bizkarguenaga, Maider; ; ; Iruarrizaga Lejarreta, Marta; Sot, Jesús; Tsvirkun, Darya; Van Liempd, Sebastiaan Martijn; Goñi Urcelay, Félix María; Alonso, Cristina; Martínez Chantar, María Luz ; ; Hayardeny, Liat; Lu, Shelly C.; Mato, José M. (Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ... -
Ascertaining the initiation of epidemic resurgences: an application to the COVID-19 second surges in Europe and the Northeast United States
(The Royal Society, 2021-10-06)[EN]Assessing a potential resurgence of an epidemic outbreak with certainty is as important as it is challenging. The low number of infectious individuals after a long regression, and the randomness associated with it, ... -
Atomistic Insights of Calmodulin Gating of Complete Ion Channels
Núñez Viadero, Eider; ; Villarroel Muñoz, Álvaro (MDPI, 2020-02-14)
Intracellular calcium is essential for many physiological processes, from neuronal signaling and exocytosis to muscle contraction and bone formation. Ca<sup>2+</sup> signaling from the extracellular medium depends both on ... -
ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP
; ; ; Zugaza Gurruchaga, José Luis; ; Marino Sánchez, Aida Luisa (Public Library of Science, 2013)
In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ... -
Autophagy-related proteins: in vitro studies of protein-lipid interactions modulating autophagosome elongation
Hervás Hidalgo, Javier (2016-03-18)
La autofagia es un proceso catabólico implicado en el desarrollo de un amplio espectro de enfermedades humanas. Se caracteriza por la formación de una estructura de doble membrana denominada autofagosoma, la cual incorpora ... -
Bases estructurales del transporte de Mg2+ mediado por los factores homeostáticos CNNM2 y CNNM4, y de su interacción oncogénica con las fosfatasas PRL.
El Magnesio, segundo catión intracelular más abundante, es un ión imprescindible en diversas funciones vitales como la neurotransmisión, la conductancia cardiaca o la síntesis de ATP. Este papel biológico trascendental ... -
BFL1 Modulates Apoptosis at the Membrane Level through a Bifunctional And Multimodal Mechanism Showing Key Differences With BCLXL
; Landeta Díaz, Olatz; Ugarte Uribe, Begoña ; ; ; ; (Springer Nature, 2018-12-18)
BFL1 is a relatively understudied member of the BCL2 protein family which has been implicated in the pathogenesis andchemoresistance of a variety of human cancers, including hematological malignancies and solid tumours. ...