ADDI: Recent submissions

Now showing items 5-8 of 38911

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      A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity 

      Bonifazi, Giulio; Luchena Moreno, Celia; Gaminde Blasco, Adhara Mikaela; Ortiz Sanz, Carolina; Capetillo González de Zarate, Estíbaliz; Matute Almau, Carlos José; Alberdi Alfonso, Elena María; De Pittà, Maurizio (Elsevier, 2024-05)
      The pathophysiological process of Alzheimer's disease (AD) is believed to begin many years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a crucial window for potential therapeutic ...
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      Eutectogels as a Semisolid Electrolyte for Organic Electrochemical Transistors 

      Zhong, Yizhou; López Larrea, Naroa; Álvarez Tirado, Marta; Casado Pérez, Nerea; Koklu, Anil; Marks, Adam; Moser, Maximilian; McCulloch, Iain; Mecerreyes Molero, David; Inal, Sahika (ACS, 2024-02)
      Organic electrochemical transistors (OECTs) are signal transducers offering high amplification, which makes them particularly advantageous for detecting weak biological signals. While OECTs typically operate with aqueous ...
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      Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects 

      De la Cuesta Barrutia, Jon; Martínez Peula, Oihane; Rivero Calera, Guadalupe; Santas Martín, Jon Ander; Munarriz Cuezva, Eva; Brocos Mosquera, Iria; Miranda Azpiazu, Patricia; Díez Alarcia, Rebeca; Morentin Campillo, Benito; Honer, William G.; Callado Hernando, Luis Felipe; Erdozáin Fernández, Amaia Maite; Ramos Miguel, Alfredo (Nature, 2024-02)
      Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu2R and mGlu3R) in brains of schizophrenia patients may explain the limited efficacy of mGlu2/3R ligands in clinical trials. ...
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      Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif 

      Pérez Jover, María Isabel; Rochon, Kristy; Hu, Di; Mahajan, Mukesh; Mohan, Pooja Madan; Santos Pérez, Isaac; Ormaetxea Gisasola, Julene; Martínez Gálvez, Juan Manuel; Agirre, Jon; Qi, Xin; Mears, Jason A.; Shnyrova Zhadan, Anna; Ramachandran, Rajesh (Nature, 2024-01)
      The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial and peroxisomal fission, but the regulatory mechanisms remain ambiguous. Here we find that a conserved, intrinsically disordered, six-residue ...