BackBrowsing by Title
Now showing items 27383-27402 of 39237
-
Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery
Jiménez Agüero, Raúl; Emparanza, José Ignacio; Beguiristain Gómez, Adolfo; Bujanda Fernández de Pierola, Luis
; Alustiza Echeberria, José María; García, Elisabeth; Hijona Muruamendiaraz, Elizabeth; Gallego, Lander; Sanchez Gonzalez, Javier; Perugorria Montiel, María Jesús; Asensio, José I; Larburu Echaniz, Santiago; Garmendia Antin, Maddi ; Larzabal, Mikel; Portillo Baquedano, María Puy ; Aguirre López, Leixuri ; Bañales Asurmendi, Jesús María (Biomed Central, 2014-08-26)
Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a ... -
Novel Evidence hat Attributing Affectively Salient Signal to Random Noise Is Associated with Psychosis
Catalán Alcántara, Ana; Simons, Claudia J. P.; Bustamante Madariaga, Sonia; Drukker, Marjan; Madrazo, Aranzazu; González de Artaza Lavesa, Maider; Gorostiza, Iñigo; Van Os, Jim; González Torres, Miguel Ángel (Public Library Science, 2014-07-14)
We wished to replicate evidence that an experimental paradigm of speech illusions is associated with psychotic experiences. Fifty-four patients with a first episode of psychosis (FEP) and 150 healthy subjects were examined ... -
Novel functions of Calmodulin in Kv7.2 regulation and co-translational folding
(2023-07-17)CaM binds to the calcium responsive domain (CRD) of voltage-gated potassium channel 7.2 (Kv7.2), transmitting calcium signaling to control its pore gating. In addition, CaM affects other functions, such as trafficking to ... -
Novel genes and sex differences in COVID-19 severity
Castaño González, Luis Antonio; ; ; (Oxford University Press, 2022-11)
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE ... -
Novel Golden Lipid Nanoparticles with Small Interference Ribonucleic Acid for Substrate Reduction Therapy in Fabry Disease
Beraza Millor, Marina; Rodríguez Castejón, Julen ; Miranda Gómez, Jonatan ; Del Pozo Rodríguez, Ana ; ; Solinís Aspiazu, María Ángeles (MDPI, 2023-07-12)
Substrate reduction therapy (SRT) has been proposed as a new gene therapy for Fabry disease (FD) to prevent the formation of globotriaosylceramide (Gb3). Nanomedicines containing different siRNA targeted to Gb3 synthase ... -
Novel hybrid organic/inorganic poly(thiourethane) covalent adaptable networks
(Elsevier, 2022-07)Organic-inorganic hybrid materials combine the advantages of both phases: hardness and strength of inorganic phase and elasticity and toughness of the organic matrix. In the present study, we have prepared nanocomposites ... -
Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass
; ; Meaurio Arrate, Emiliano; ; ; Sarasua Oiz, José Ramón (MDPI, 2021-02-25)
Chitosan (CS) and poly(vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are ... -
Novel insights in the pathogenesis of primary biliary cholangitis and cholangiocarcinoma
(2017-06-23)Este trabajo de tesis doctoral se centra en el estudio de dos enfermedades biliares: la colangitis biliar primaria (del inglés primary biliary cholangitis, PBC) y el colangiocarcinoma (CCA).Por un lado, ya que el miR-506 ... -
Novel insights into the corrosion mechanism of decorative multilayer nickel-chromium coatings on ABS: towards a correltion between CASS and electrochemical tests.
(2020-11-05)La presente tesis doctoral aborda la temática de la corrosión de los recubrimientos multicapa níquelcromocentrándose en el alcance de los siguientes objetivos: (1) conocer el mecanismo de corrosión bajocondiciones de ensayo ... -
Novel Loci for Childhood Body Mass Index and Shared Heritability with Adult Cardiometabolic Traits
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bilbao Catalá, José Ramón; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Public Library Science, 2020-10-12)
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ... -
Novel Mean-Type Inequalities via Generalized Riemann-Type Fractional Integral for Composite Convex Functions: Some Special Examples
; ; ; ; ; De la Sen Parte, Manuel; (MDPI, 2023-02-10)
This study deals with a novel class of mean-type inequalities by employing fractional calculus and convexity theory. The high correlation between symmetry and convexity increases its significance. In this paper, we first ... -
Novel mechanisms for regulation of cell survival and migration by ceramide 1-phosphate
(2014-02-07)Ceramide 1-phosphate is a bioactive sphingolipid that regulates important cell functions, including cell proliferation, apoptosis, migration or inflammation. Cell homeostasis is essential for the normal development of any ... -
Novel Methodology for the Detection of Enveloped Viruses
(MDPI, 2020-06-15)Viral infections in humans cause a huge burden in worldwide healthcare that has increased due to the emergence of new pathogenic viruses, such as in the recent Ebola virus (EBOV) outbreaks. Viral particles in body fluids ... -
Novel methods for stereocontrolled cycloaddition/dearomatization reactions under catalytic conditions
(2017-04-28)Los alcaloides son, en general, una familia de compuestos heterocíclicos de origen vegetal que incorporan átomos de nitrógeno en su compleja estructura. Su interés recae en las interesantes actividades biológicas que ... -
Novel multivariate methods to track frequency shifts of neural oscillations in EEG/MEG recordings
(ELSEVIER, 2023)Instantaneous and peak frequency changes in neural oscillations have been linked to many perceptual, motor, and cognitive processes. Yet, the majority of such studies have been performed in sensor space and only occasion- ally ... -
Novel nanostructured lipid carriers based on Ω-3 polyunsaturated fatty acids and TAT peptide for neurodegenerative disease treatment
(2020-12-14)Neurodegenerative diseases (NDs) are an accelerating global problem, but we still lack routes to develop effective therapeutics. In this quest, it is crucial to identify novel drug candidates or drug carriers, which cross ... -
Novel organized multi-enzyme systems based on protein scaffolding
(2023-09-29)Este trabajo presenta tres estrategias versátiles para organizar sistemas multi-enzimáticos mediante el diseño de proteínas, creando andamiajes que combinan la organización espacial con la captura específica de intermediarios ... -
Novel Papillomaviruses in Free-Ranging Iberian Bats: No Virus-Host Co-evolution, No Strict Host Specificity, and Hints for Recombination
García Pérez, Raquel; Ibáñez, Carlos; Godínez, José M.; Aréchiga, Nidia; Garín Atorrasagasti, Ignacio; Pérez Suárez, Gonzalo; De Paz, Oscar; Juste, Javier; Echevarría, Juan E.; Bravo, Ignacio G. (Oxford University Press, 2014)
Papillomaviruses (PVs) are widespread pathogens. However, the extent of PV infections in bats remains largely unknown. This work represents the first comprehensive study of PVs in Iberian bats. We identified four novel PVs ... -
Novel phosphine sulphide gold(I) complexes: topoisomerase I inhibitors and antiproliferative agents
; ; ; ; Rubiales Alcaine, María Gloria; ; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (RSC, 2020-05-20)
This work describes the synthesis of the gold(I) complexes of phosphine sulphides. The formation of these new derivatives has been confirmed by X-ray crystallography. The coordination of gold(I) with the sulphur atom of ... -
Novel Pixelwise Co-Registered Hematoxylin-Eosin and Multiphoton Microscopy Image Dataset for Human Colon Lesion Diagnosis
Picón Ruiz, Artzai; Terradillos Fernández, Elena; Sánchez Peralta, Luisa F.; Mattana, Sara; Cicchi, Riccardo; Blover, Benjamin J.; Arbide del Río, Nagore; Velasco Arteche, Jacques; Etxezarraga Zuluaga, María Carmen; Pavone, Francesco S.; Garrote Contreras, Estíbaliz; López Saratxaga, Cristina (Elsevier, 2022-02-07)
Colorectal cancer presents one of the most elevated incidences of cancer worldwide. Colonoscopy relies on histopathology analysis of hematoxylin-eosin (H&E) images of the removed tissue. Novel techniques such as multi-photon ...