BackBrowsing by Author "Caaveiro, Jose M.M."
Now showing items 1-6 of 6
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Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments
; ; ; ; ; ; Sánchez Eugenia, Rubén
; ; ; ; ; ; ; ; ; ; ; ; (Cell Press, 2020-08-18)
The contribution of membrane interfacial interactions to recognition of membrane-embedded antigens by antibodies is currently unclear. This report demonstrates the optimization of this type of antibodies via chemical ... -
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile
; ; ; ; ; ; ; Sánchez Eugenia, Rubén; ; ; ; ; ; ; ; ; (Cell Press, 2021-09-24)
Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the ... -
Functional Delineation of a Protein–Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8
; ; Torralba Iturbe, Johana; ; ; De la Arada Echevarría, Igor ; Apellaniz Unzalu, Beatriz ; ; ; ; ; (MDPI, 2022-09-15)
Antibody engagement with the membrane-proximal external region (MPER) of the envelope glycoprotein (Env) of HIV-1 constitutes a distinctive molecular recognition phenomenon, the full appreciation of which is crucial for ... -
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
Torralba Iturbe, Johana; De la Arada Echevarría, Igor ; ; ; ; ; ; ; ; ; ; Apellaniz Unzalu, Beatriz ; ; (Nature, 2022)
Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ... -
Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface
; ; ; ; ; Apellaniz Unzalu, Beatriz; ; ; ; ; ; (Springer Nature, 2016-12-01)
The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and ... -
The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region
Apellaniz Unzalu, Beatriz; ; ; ; ; ; ; (Elsevier, 2015-03-18)
The membrane-proximal external region (MPER) C-terminal segment and the transmembrane domain (TMD) of gp41 are involved in HIV-1 envelope glycoprotein-mediated fusion and modulation of immune responses during viral infection. ...