BackBrowsing by Author "Caaveiro, Jose M.M."
Now showing items 1-4 of 4
-
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments
; ; ; Carravilla Palomanes, Pablo
; ; ; Sánchez Eugenia, Rubén ; ; ; ; ; ; ; ; ; ; ; ; (Cell Press, 2020-08-18)
The contribution of membrane interfacial interactions to recognition of membrane-embedded antigens by antibodies is currently unclear. This report demonstrates the optimization of this type of antibodies via chemical ... -
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile
; ; ; Carravilla Palomanes, Pablo; ; ; ; Sánchez Eugenia, Rubén ; ; ; ; ; ; ; ; ; (Cell Press, 2021-09-24)
Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the ... -
Functional Delineation of a Protein–Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8
; ; Torralba Iturbe, Johana; ; ; De la Arada Echevarría, Igor ; Apellaniz Unzalu, Beatriz ; ; Carravilla Palomanes, Pablo ; ; ; (MDPI, 2022-09-15)
Antibody engagement with the membrane-proximal external region (MPER) of the envelope glycoprotein (Env) of HIV-1 constitutes a distinctive molecular recognition phenomenon, the full appreciation of which is crucial for ... -
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
Torralba Iturbe, Johana; De la Arada Echevarría, Igor ; ; ; ; ; ; ; ; ; ; Apellaniz Unzalu, Beatriz ; ; (Nature, 2022)
Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ...