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2-Interleukina (IL-2) eta IL-15 seinalizazio bidezidorrak T linfozitoetan: antzekoak baina aldiberean ezberdinak

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Date
2016
Author
Osinalde Moraleja, Nerea
Omaetxebarria Ibarra, Miren Josu
Sánchez Quiles, Virginia
Akimov, Vyacheslav
Blagoev, Blagoy
Kratchmarova, Irina
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Ekaia N. Extra : 69-76 (2016)
URI
http://hdl.handle.net/10810/38921
Abstract
2-interleukina (IL-2) eta IL-15 zitokinek berebiziko garrantzia daukate sistema immunologikoaren erregulazioan, besteak beste T linfozitoen proliferazioa sustatzen dutelako. Zitokina biek bi hartzaile-azpiunitate partekatzen dituztenez (IL-2Rβ eta IL-2Rγ) ez da harritzekoa teilakatutako hainbat funtzio izatea, baina bai da harrigarria, ordea, bakoitzak erantzun immunologiko espezikoak eta maiz kontrajarriak eragitea. Nahiz eta mekanismo asko proposatu diren IL-2 eta IL-15 arteko desberdintasunak azaltzeko, ez dago argi nola den posible biek, hartzaile berdinak erabiltzen dituztelarik, zeluletan erantzun desberdinak sustatzea. Horren gakoa aurkitzeko asmoz, IL-2 eta IL-15ez kitzikatutako T-zeluletan piztutako seinalizazio-bidezidorrak aztertu eta elkarren artean konparatu ditugu, masa-espektrometria erabilita. Gure lanak erakutsi du bi zitokinek kitzikatutako T linfozitoen seinalizazio-sareak oso parekoak izan arren, badirela ñabardura batzuk bi zitokinen arteko alde funtzionala azaltzen lagun dezaketenak.; L-2 and IL-15 are key cytokines regulating the immune system i n part by promoting T-cell proliferation. Both cytokines signal through the same receptor subunits (IL-2Rβ and IL-2Rγ) and not surprisingly they exert some overlapping functions. However they also have specific and even sometimes opposing roles raising the paradigm of how they mediate distinct immune reponses by using the same receptors. Although several options have been suggested, it remains controversial the molecular mechanism underlying the functional dichotomy of IL-2 and IL-15. Aiming to find the key to answering such enigma, we assessed and compared by mass spectrometry the signaling networks activated by both cytokines. Our study revealed that the transduction pathways initiated by IL-2 and IL-15 are highly similar but not identical since we detected faint differences that may account for the functional discrepancy observed between both cytokines.
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