INVESTIGACIÓN
Recent Submissions
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Pharmacogenomics of intracellular methotrexate polyglutamates in leukemia cells, in vivo
(American Society for Clinical Investigation, 2020-11-09)BACKGROUNDInterpatient differences in the accumulation of methotrexate's active polyglutamylated metabolites (MTXPGs) in leukemia cells influence its antileukemic effects.METHODSTo identify genomic and epigenomic and patient ... -
Genetic variants associated with methotrexate-induced mucositis in cancer treatment: a systematic review and meta-analysis.
(Elsevier, 2021-03-29)Methotrexate (MTX), an important chemotherapeutic agent, is often accompanied with mucositis. The occurrence and severity are unpredictable and show large interindividual variability. In this study, we review and meta-analyze ... -
Differential protein and mRNA cargo loading into engineered large and small extracellular vesicles reveals differences in in vitro and in vivo assays
(Elsevier, 2025-02-03)Extracellular vesicles (EV) represent an advanced platform for genetic material and protein delivery, particularly when they are loaded through the so-called endogenous loading method. This study investigates the differences ... -
Arqueometría de los materiales cerámicos de época medieval en España
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2018)Este es el primer volumen dedicado a la arqueometría de los materiales cerámicos de época medieval en España. El libro acoge un total de trece trabajos, que recogen los resultados de algunos de los principales proyectos ...