IKERKUNTZA;;INVESTIGACIÓN: Recent submissions

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      Pharmacogenomics of intracellular methotrexate polyglutamates in leukemia cells, in vivo 

      López López, Elixabet; Autry, Robert J.; Smith, Colton; Yang, Wenjian; Paugh, Steven W.; Panetta, John C.; Crews, Kristine R.; Bonten, Erik J.; Smart, Brandon; Pei, Deqing; McCorkle, J. Robert; Diouf, Barthelemy; Roberts, Kathryn G.; Shi, Lei; Pounds, Stanley; Cheng, Cheng; Mullighan, Charles G.; Pui, Ching-Hon; Relling, Mary V.; Evans, William E. (American Society for Clinical Investigation, 2020-11-09)
      BACKGROUNDInterpatient differences in the accumulation of methotrexate's active polyglutamylated metabolites (MTXPGs) in leukemia cells influence its antileukemic effects.METHODSTo identify genomic and epigenomic and patient ...
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      Genetic variants associated with methotrexate-induced mucositis in cancer treatment: a systematic review and meta-analysis. 

      Maagdenberg, Hedy; Oosterom, Natanja; Zanen, Jolanda; Gemmati, Donato; Windsor, Rachael E.; Heil, Sandra G.; Esperón, Patricia; Jabeen, Shakila; Ruiz Argüelles, Guillermo J.; Zolk, Oliver; Hoerning, Susanne; Sleurs, Charlotte; López López, Elixabet; Moreno Galván, Mónica; van den Heuvel-Eibrink, Marry M.; Maitland-van der Zee, Anke H.; Carleton, Bruce C. (Elsevier, 2021-03-29)
      Methotrexate (MTX), an important chemotherapeutic agent, is often accompanied with mucositis. The occurrence and severity are unpredictable and show large interindividual variability. In this study, we review and meta-analyze ...
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      Differential protein and mRNA cargo loading into engineered large and small extracellular vesicles reveals differences in in vitro and in vivo assays 

      Eraña Pérez, Zuriñe; Igartua Olaechea, Manuela; Santos Vizcaíno, Edorta; Hernández Martín, Rosa María (Elsevier, 2025-02-03)
      Extracellular vesicles (EV) represent an advanced platform for genetic material and protein delivery, particularly when they are loaded through the so-called endogenous loading method. This study investigates the differences ...
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      Arqueometría de los materiales cerámicos de época medieval en España 

      Proyecto EARMEDCASTILE (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2018)
      Este es el primer volumen dedicado a la arqueometría de los materiales cerámicos de época medieval en España. El libro acoge un total de trece trabajos, que recogen los resultados de algunos de los principales proyectos ...