Browsing INVESTIGACIÓN by Author "Saavedra, Ana"

Now showing items 1-3 of 3

    • Thumbnail

      Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61) levels 

      Xu, Jian; Kurup, Pradeep; Azkona Mendoza, Garikoitz ORCID; Baguley, Tyler D.; Saavedra, Ana; Nairn, Angus C.; Ellman, Jonathan A.; Pérez Navarro, Esther; Lombroso, Paul J. (Wiley, 2015-08-28)
      Brain-derived neurotrophic factor (BDNF) regulates synaptic strengthening and memory consolidation, and altered BDNF expression is implicated in a number of neuropsychiatric and neurodegenerative disorders. BDNF potentiates ...
    • Thumbnail

      Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning 

      Saavedra, Ana; Ballesteros, Jesus J; Tyebji, Shiraz; Martinez-Torres, Sara; Blazquez, Gloria; Lopez-Hidalgo, Rosa; Azkona Mendoza, Garikoitz ORCID; Alberch, Jordi; Martin, Eduardo D; Pérez Navarro, Esther (Springer Nature, 2018-06-12)
      Striatal-enriched protein tyrosine phosphatase (STEP) modulates key signaling molecules involved in synaptic plasticity and neuronal function. It is postulated that STEP opposes the development of long-term potentiation ...
    • Thumbnail

      Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition 

      Azkona, Garikoitz ORCID; Saavedra, Ana; Aira Muga, Zigor; Aluja, David; Xifró, Xavier; Baguley, Tyler D.; Alberch, Jordi; Ellman, Jonathan A.; Lombroso, Paul J.; Azkue Barrenetxea, Jon Jatsu; Pérez Navarro, Esther (International Association for the Study of Pain, 2016-02)
      The information from nociceptors is processed in the dorsal horn of the spinal cord by complex circuits involving excitatory and inhibitory interneurons. It is well documented that GluN2B and ERK1/2 phosphorylation contributes ...