BackExaminar INVESTIGACIÓN por departamento (eus.) "Farmakologia"
Now showing items 1-20 of 197
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6-Hydroxydopamine lesion and levodopa treatment modif y the effect of buspirone in the substantia nigra pars reticulata
Vegas Suárez, Sergio
; ; Requejo Rodríguez, Catalina ; ; Lafuente Sánchez, José Vicente ; ; ; (Wiley, 2020-09)
Background and Purpose l-DOPA-induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5-HT(1A)partial agonist) have shown promising results in the treatment of ... -
A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users
(Nature Research, 2021-10-07)[EN]Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable ... -
A novel double-hit animal model of schizophrenia: behavioural assessment in male and female mice
Muguruza Millán, Carolina; Cordero Ruiz, Natalia ; Meana Martínez, José Javier ; (Elsevier, 2020-11-17)
Background: A growing body of evidence support that maternal prenatal infections represent a risk factor for schizophrenia in offspring. Moreover, stressful events during critical neurodevelopmental periods, such as ... -
Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats
(Oxford University Press, 2017-06)Background: There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with ... -
Actividad in vitro de anidulafungina, caspofungina y micafungina contra especies crípticas de Candida: curvas de letalidad, efecto postantifúngico y modelización farmacocinética/farmacodinámica
Gil Alonso, Sandra (2015-06-18)
Las candidiasis son las micosis invasivas más frecuentes y una importante causa de morbilidad ymortalidad. Candida albicans es la especie predominante pero otras especies de este género la estándesplazando etiológicamente, ... -
Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease
Manuel Vicente, Iván; ; ; ; Rodríguez Puertas, Rafael (Elsevier, 2016-05-17)
Las alteraciones neuroquímicas en la enfermedad de Alzheimer (EA) incluyen la pérdida neuronal colinérgica en el núcleo basal de Meynert (nbM) y una disminución de las densidades del subtipo de receptor muscarínico M2 en ... -
Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats
(Elsevier, 2019-12)The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of oscillatory activity and synchronization in several basal ganglia ... -
Alcohol triggers the accumulation of oxidatively damaged proteins in neuronal cells and tissues
; ; ; ; ; ; Callado Hernando, Luis Felipe; (MDPI, 2024-05-08)
Alcohol is toxic to neurons and can trigger alcohol-related brain damage, neuronal loss, and cognitive decline. Neuronal cells may be vulnerable to alcohol toxicity and damage from oxidative stress after differentiation. ... -
Alcohol-Related Brain Damage in Humans
Erdozain Fernández, Amaia Maite; ; ; ; ; ; ; ; ; ; Callado Hernando, Luis Felipe ; (Public Library Science, 2014-04-03)
Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control ... -
Altered neuronal activity and differential sensitivity to acute antidepressants of locus coeruleus and dorsal raphe nucleus in Wistar Kyoto rats: a comparative study with Sprague Dawley and Wistar rats
Bruzos Cidón, Cristina; ; ; ; ; Torrecilla Sesma, María (Elsevier, 2014-02-19)
The Wistar Kyoto rat (WKY) has been proposed as an animal model of depression. The noradrenergic nucleus, locus coeruleus (LC) and the serotonergic nucleus, dorsal raphe (DRN) have been widely implicated in the ethiopathology ... -
Analysis of Mitochondrial Function in Cell Membranes as Indicator of Tissue Vulnerability to Drugs in Humans
Elexpe, Ane; Sánchez-Sánchez, Laura; Tolentino-Cortez, Tarson; Astigarraga Arribas, Egoitz; Torrecilla Sesma, María; Barreda Gómez, Gabriel (MDPI, 2022-04-23)
Drug side effects are one of the main reasons for treatment withdrawal during clinical trials. Reactive oxygen species formation is involved in many of the drug side effects, mainly by interacting with the components of ... -
Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry
; ; ; Manuel Vicente, Iván; ; ; ; ; Rodríguez Puertas, Rafael ; Fernández González, José Andrés (Springer Verlag, 2011-01-28)
[ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ... -
Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain
González de San Román, Estibaliz; Manuel Vicente, Iván ; ; ; ; ; ; ; Rodríguez Puertas, Rafael (John Wiley & Sons, 2015-04-10)
El ácido lisofosfatídico (LPA) es una molécula de señalización que se une a seis receptores acoplados a proteínas G conocidos: LPA1 -LPA6 . El LPA evoca varias respuestas en el SNC, entre ellas el desarrollo y plegamiento ... -
Application of a dual mechanistic approach to support bilastine dose selection for older adults
(Wiley, 2021-09)The objective of this study was to evaluate bilastine dosing recommendations in older adults and overcome the limitation of insufficient data from phase I studies in this underrepresented population. This was achieved by ... -
Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover
Plaza Zabala, Ainhoa; ; (Frontiers Media, 2021-01-29)
Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly ... -
Automated procedure to detect subtle motor alterations in the balance beam test in a mouse model of early Parkinson’s disease
(Nature, 2024)Parkinson’s disease (PD) is the most common motor neurodegenerative disorder, characterised by aggregated α-synuclein (α-syn) constituting Lewy bodies. We aimed to investigate temporal changes in motor impairments in a PD ... -
Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia
Urigüen Echeverría, Leyre; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Meana Martínez, José Javier (Nature Publishing Group, 2013-01)
Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter ... -
Behavioural Evaluation of a Translational Animal Model of Schizophrenia
Cordero Ruiz, Natalia; Muguruza Millán, Carolina ; Pérez del Palomar Asín, Blanca ; ; Meana Martínez, José Javier ; (Wiley, 2018-08)
Schizophrenia (SZ) is a chronic and disabling psychiatric disorder affecting about 1% of the population worldwide. Schizophrenia comprises positive and negative symptoms as well as cognitive deficits. Epidemiological and ... -
Biochemical and functional charactrization of the CB1 cannabinoid recptor coupling to Gai/l proteins in synaptosomal membranes from hippocampus and frontal cortex of cell-type-specifc mutant mouse rescue model
(2021-05-18)Egun, ezaguna da terminal sinaptiko glutamatergiko eta GABAergikoetan espresatzen den CB1 hartzailearen aktibazioak aktibitate neuronal eszitatzaile-inhibitzailearen balantzea erregulatzen duela. Horregatik, bi terminal ... -
Bioinformatics of warfarin personalized medicine for cardiac surgery patients
(2024-06-24)Warfarin has a large individual variability and many factors contribute to its variability. Mathematical models can quantify the impact of the factors. This study explored the effect of intravenous antibiotics on gut ...