Now showing items 1-20 of 148

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      A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold 

      Rendón Ramírez, Adela; Shukla, Manish; Oda, Masataka; Chakraborty, Sandeep; Minda, Renu; Dandekar, Abhaya M.; Asgeirsson, Bjarni; Goñi Urcelay, Félix María ORCID; Rao, Basuthkar J. (Public Library Science, 2013-08)
      Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous ...
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      A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene 

      Ibarrola Villava, Maider; Fernandez, Lara P.; Alonso Alegre, Santos ORCID; Boyano López, María Dolores ORCID; Peña Chilet, María; Pita, Guillermo; Avilés, José A.; Mayor, Matias; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Izagirre Arribalzaga, Neskuts ORCID; De la Rúa Vaca, Concepción ORCID; Asumendi Mallea, Aintzane ORCID; Pérez-Yarza Pérez-Irezabal, Gorka ORCID; Arroyo Berdugo, Yoana; Boldo, Enrique; Lozoya, Rafael; Torrijos Aguilar, Arantxa; Pitarch, Ana; Pitarch, Gerard; Sánchez Motilla, José M.; Valcuende Cavero, Francisca; Tomás Cabedo, Gloria; Pérez Pastor, Gemma; Díaz Pérez, José Luis; Gardeazabal García, Jesús; Martínez de Lizarduy, Iñigo; Sánchez Díez, Ana; Valdés, Carlos; Pizarro, Angel; Casado, Mariano; Carretero, Gregorio; Botella Estrada, Rafael; Nagore, Eduardo; Lázaro, Pablo; Lluch, Ana; Benítez, Javier; Martínez Cadenas, Conrado; Ribas, Gloria (Public Library of Science, 2011-04-29)
      As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ...
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      A Delphi Process to Optimize Quality and Performance of Drug Evaluation in Neonates 

      Legrand, Frederic; Boulkedid, Rym; Elie, Valery; Leroux, Stephanie; Valls, Elizabeth; Valls Soler, Adolfo; Van den Anker, Johannes N.; Jacqz-Aigrain, Evelyne (Public Library Science, 2014-09-11)
      Background: Neonatal trials remain difficult to conduct for several reasons: in particular the need for study sites to have an existing infrastructure in place, with trained investigators and validated quality procedures ...
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      A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer 

      Antelo, Marina; Balaguer, Francesc; Shia, Jinru; Shen, Yan; Hur, Keun; Moreira, Leticia; Cuatrecasas, Miriam; Bujanda Fernández de Pierola, Luis ORCID; Giraldez, María Dolores; Takahashi, Masanobu; Cabanne, Ana; Barugel, Mario Edmund; Arnold, Mildred; Roca, Enrique Luis; Andreu, Montserrat; Castellví-Bel, Sergi; Llor, Xavier; Jover, Rodrigo; Castells, Antoni; Boland, C. Richard; Goel, Ajay (Public Library of Science, 2012-09-25)
      Objective: Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized ...
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      A Model of Ischemia-Induced Neuroblast Activation in the Adult Subventricular Zone 

      Vergni, Davide; Castiglione, Filippo; Briani, Maya; Middei, Silvia; Alberdi Alfonso, Elena María ORCID; Reymann, Klaus G.; Natalini, Roberto; Volonté, Cinzia; Matute Almau, Carlos José ORCID; Cavaliere, Fabio (Public Library of Science, 2009-04-23)
      We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia. Neuroblast activation has ...
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      A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation 

      Di Penta, Alessandra; Chiba, Asako; Alloza Moral, Iraide; Wyssenbach Ibarra, Ane; Yamamura, Takashi; Villoslada, Pablo; Miyake, Sachiko; Vandenbroeck, Koen (Public Library of Science, 2013-12-11)
      Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ...
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      Accuracy in Copy Number Calling by qPCR and PRT : A Matter of DNA 

      Fernández-Jiménez, Nora; Castellanos Rubio, Ainara; Plaza-Izurieta, Leticia; Gutiérrez, Galder; Irastorza Terradillos, Iñaki Xarles ORCID; Castaño González, Luis Antonio ORCID; Vitoria Cormenzana, Juan Carlos; Bilbao Catalá, José Ramón ORCID (Public Library of Science, 2011-12-13)
      The possible implication of copy number variation (CNV) in the genetic susceptibility to human disease needs to be assessed using robust methods that can be applied at a population scale. In this report, we analyze the ...
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      Adenylate Cyclase Toxin Promotes Internalisation of Integrins and Raft Components and Decreases Macrophage Adhesion Capacity 

      Martín Plágaro, César Augusto ORCID; Belloso Uribe, Kepa; Gómez Bilbao, Geraxane; Ostolaza Echabe, Elena Amaya ORCID (Public Library of Science, 2011-02-23)
      Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active. The toxin targets phagocytes ...
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      Advantages and Versatility of Fluorescence-Based Methodology to Characterize the Functionality of LDLR and Class Mutation Assignment 

      Echevarria Gallego, Aitor; Benito Vicente, Asier ORCID; Ostolaza Echabe, Elena Amaya ORCID; Martín Plágaro, César Augusto ORCID (Public Library Science, 2014-11-11)
      Familial hypercholesterolemia (FH) is a common autosomal codominant disease with a frequency of 1:500 individuals in its heterozygous form. The genetic basis of FH is most commonly mutations within the LDLR gene. Assessing ...
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      Alcohol-Related Brain Damage in Humans 

      Erdozain Fernández, Amaia Maite ORCID; Morentin Campillo, Benito; Bedford, Lynn; King, Emma; Tooth, David; Brewer, Charlotte; Wayne, Declan; Johnson, Laura; Gerdes, Henry K.; Wigmore, Peter; Callado Hernando, Luis Felipe ORCID; Carter, Wayne G. (Public Library Science, 2014-04-03)
      Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control ...
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      Ancient DNA from Hunter-Gatherer and Farmer Groups from Northern Spain Supports a Random Dispersion Model for the Neolithic Expansion into Europe 

      Hervella Afonso, Montserrat ORCID; Izagirre Arribalzaga, Neskuts ORCID; Alonso Alegre, Santos ORCID; Fregel, Rosa; Alonso, Antonio; Cabrera, Vicente M.; De la Rúa Vaca, Concepción ORCID (Public Library of Science, 2012-04-25)
      Background/Principal Findings: The phenomenon of Neolithisation refers to the transition of prehistoric populations from a hunter-gatherer to an agro-pastoralist lifestyle. Traditionally, the spread of an agro-pastoralist ...
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      Ancient DNA from South-East Europe Reveals Different Events during Early and Middle Neolithic Influencing the European Genetic Heritage 

      Hervella Afonso, Montserrat ORCID; Rotea, Mihai; Izagirre Arribalzaga, Neskuts ORCID; Constantinescu, Mihai; Alonso Alegre, Santos ORCID; Ioana, Mihai; Lazăr, Cătălin; Ridiche, Florin; Soficaru, Andrei Dorian; Netea, Mihai G.; De la Rúa Vaca, Concepción ORCID (Public Library Science, 2015-06-08)
      The importance of the process of Neolithization for the genetic make-up of European populations has been hotly debated, with shifting hypotheses from a demic diffusion (DD) to a cultural diffusion (CD) model. In this regard, ...
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      Antibody Complementarity-Determining Regions (CDRs) Can Display Differential Antimicrobial, Antiviral and Antitumor Activities 

      Polonelli, Luciano; Pontón, José; Elguezabal Vega, Natalia María; Moragues Tosantos, María Dolores ORCID; Casoli, Claudio; Pilotti, Elisabetta; Ronzi, Paola; Dobroff, Andrey S.; Rodrigues, Elaine G.; Juliano, Maria A.; Maffei, Domenico Leonardo; Magliani, Walter; Conti, Stefania; Travassos, Luiz R. (Public Library of Science, 2008-06-11)
      Background: Complementarity-determining regions (CDRs) are immunoglobulin (Ig) hypervariable domains that determine specific antibody (Ab) binding. We have shown that synthetic CDR-related peptides and many decapeptides ...
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      Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity 

      Orzáez, Mar; Sancho, Mónica; Marchán, Sandra; Mondragón, Laura; Montava, Rebeca; García Valero, Juan; Landeta Díaz, Olatz ORCID; Basáñez Asúa, Gorka; Carbajo, Rodrigo J.; Pineda-Lucena, Antonio; Bujons, Jordi; Moure, Alejandra; Messeguer, Angel; Lagunas, Carmen; Herrero, Carmen; Pérez- Payá, Enrique (Public Library Science, 2014-10-20)
      Background: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although ...
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      Association between CASP8-652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study 

      Pardini, Barbara; Verderio, Paolo; Pizzamiglio, Sara; Nici, Carmela; Maiorana, Maria Valeria; Naccarati, Alessio; Vodickova, Ludmila; Vymetalkova, Veronika; Veneroni, Silvia; Daidone, Maria Grazia; Ravagnani, Fernando; Bianchi, Tiziana; Bujanda Fernández de Pierola, Luis ORCID; Carracedo, Angel; Castells, Antoni; Ruiz Ponte, Clara; Morreau, Hans; Howarth, Kimberley; Jones, Angela; Castellví-Bel, Sergi; Li, Li; Tomlinson, Ian; Van Wezel, Tom; Vodicka, Pavel; Radice, Paolo; Peterlongo, Paolo; EPICOLON Consortium (Public Library Science, 2014-01)
      The common 2652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) ...
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      ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP 

      Burzaco Galán, Jaione; Conde Fernández, Manuel; Parada, Luis A.; Zugaza Gurruchaga, José Luis ORCID; Dehaye, Jean-Paul; Marino Sánchez, Aida Luisa ORCID (Public Library of Science, 2013)
      In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ...
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      Autophagic Marker MAP1LC3B Expression Levels Are Associated with Carotid Atherosclerosis Symptomatology 

      Swaminathan, Bhairavi; Goikuria Iriondo, Haize; Vega, Reyes; Rodríguez-Antigüedad Zarranz, Alfredo; López Medina, Antonio; Freijo, María del Mar; Vandenbroeck, Koen; Alloza Moral, Iraide (Public Library Science, 2014-12-12)
      Objectives: The mechanism by which atheroma plaque becomes unstable is not completely understood to date but analysis of differentially expressed genes in stable versus unstable plaques may provide clues. This will be ...
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      Biotic vs. Abiotic Control of Decomposition: A Comparison of the Effects of Simulated Extinctions and Changes in Temperature 

      Boyero González, María Luz ORCID; Cardinale, Bradley J.; Bastian, Mikis; Pearson, Richard G. (Public Library of Science, 2014-01)
      The loss of species is known to have significant effects on ecosystem functioning, but only recently has it been recognized that species loss might rival the effects of other forms of environmental change on ecosystem ...
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      Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study 

      González Pinto Arrillaga, Ana María ORCID; Córdova-Palomera, Aldo; Alemany, Silvia; Fatjó-Vilas, Mar; Goldberg, Ximena; Leza, Juan Carlos; Nenadic, Igor; Fañanás, Lourdes (Public Library Science, 2014-08-29)
      Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that ...
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      Ca2+ Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin (ACT) Endocytosis. Cell Physiology and Expression of the CD11b/CD18 Integrin Major Determinants of the Entry Route 

      Belloso Uribe, Kepa; Martín Plágaro, César Augusto ORCID; Etxebarria, Aitor; González Bullón, David ORCID; Gómez Bilbao, Geraxane; Ostolaza Echabe, Elena Amaya ORCID (Public Library Publishing, 2013-09)
      Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and ...