BackBrowsing INVESTIGACIÓN by Subject "IMMUNOLOGY AND MICROBIOLOGY"
Now showing items 1-18 of 18
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Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy
(Nature Publishing Group, 2014-05)Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be ... -
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels
Ruiz Núñez, Asier
; Alberdi Alfonso, Elena María ; (Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ... -
Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain
Gil de la Pisa, Itziar; Cebrián, Carolina; Ortega Calvo, Jorge; Meana Martínez, José Javier; Sulzer, David (Biomed Central, 2014-07-29)
Background: An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ... -
Data Preprocessing and Model Design for Medicine Problems
(Hindawi Publishing Corporation, 2013)... -
Differential activity of GSK-3 isoforms regulates NF-kappa B and TRAIL- or TNF alpha induced apoptosis in pancreatic cancer cells
Zhang, J.S.; Herreros Villanueva, Marta; Koenig, A.; Deng, Z.; M De Narvajas, A. A.; Gómez, T. S.; Meng, X.; Bujanda Fernández de Pierola, Luis; Ellenrieder, V.; Li, X. K.; Kaufmann, S. H.; Billadeau, D. D. (Nature Publishing Group, 2014-03)
While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting ... -
Effects of Spring Temperatures on the Strength of Selection on Timing of Reproduction in a Long-Distance Migratory Bird
(Public Library Science, 2015-04)Climate change has differentially affected the timing of seasonal events for interacting trophic levels, and this has often led to increased selection on seasonal timing. Yet, the environmental variables driving this ... -
FTY720 attenuates excitotoxicity and neuroinflammation
Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; (BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ... -
HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
(Public Library Science, 2014-07)Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism ... -
Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease
(Nature Publishing Group, 2010-01)The formation of cerebral senile plaques composed of amyloid beta peptide (A beta) is a fundamental feature of Alzheimer's disease (AD). Glial cells and more specifically microglia become reactive in the presence of A beta. ... -
Increased expression of cystine/glutamate antiporter in multiple sclerosis
Pampliega Ormaetxea, Olatz; Domercq García, María ; Soria Lannes, Federico Nicolás ; ; ; (BioMed Central, 2011-06-03)
Background: Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which ... -
Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study
(Hindawi Publishing, 2014)Introduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular ... -
Inflammatory Mediators of Hepatic Steatosis
Hijona Muruamendiaraz, Elizabeth; Hijona Muruamendiaraz, Lander; Arenas Mirave, Juan Ignacio; Bujanda Fernández de Pierola, Luis (Hindawi Publishing Corporation, 2010)
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a world-wide public health problem. NAFLD represents a spectrum of disease ranging from “simple steatosis”, which is considered relatively benign, to nonalcoholic ... -
Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes
Ruiz Núñez, Asier; ; Alberdi Alfonso, Elena María (Nature Publishing Group, 2010-07)
Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ... -
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Abiega Etxabe, Oihane; Beccari Galeano, Marlene Soledad; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq García, María; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris Guerrero, Ignacio; Valero Gómez-Lobo, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco Ruiz, María del Mar; ; Maletic-Savatic, Mirjana; Encinas Pérez, Juan Manuel; Sierra Saavedra, Amanda (2016)
Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ... -
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; (Nature Publishing Group, 2012-02)
We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ... -
Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus
(Public Library of Science, 2013-01-03)The biosynthesis of membrane lipids is an essential pathway for virtually all bacteria. Despite its potential importance for the development of novel antibiotics, little is known about the underlying signaling mechanisms ... -
The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli
(Public Library of Science, 2011-07-05)Formation of the 30S initiation complex (30S IC) is an important checkpoint in regulation of gene expression. The selection of mRNA, correct start codon, and the initiator fMet-tRNA(fMet) requires the presence of three ... -
Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis
Laín Torre, Ana; Elguezabal Vega, Natalia María; Amutio, Elena; Fernández de Larrinoa Santamaría, Iñigo; Moragues Tosantos, María Dolores; Pontón, José (Hindawi Publishing Corporation, 2008)
Invasive candidiasis is a frequent and often fatal complication in immunocompromised and critically ill patients. Unfortunately, the diagnosis of invasive candidiasis remains difficult due to the lack of specific clinical ...