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Low Molecular Weight Chitosan (LMWC)-based Polyplexes for pDNA Delivery: From Bench to Bedside
(MDPI, 2014-06)
Non-viral gene delivery vectors are emerging as a safer alternative to viral vectors. Among natural polymers, chitosan (Ch) is the most studied one, and low molecular weight Ch, specifically, presents a wide range of ...
Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
(Dove Medical Press, 2014)
Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from either positive-strand or negative-strand RNA viruses. The gene sequences encoding structural proteins in these RNA viruses are ...
A randomised controlled trial of a program based on the theory of planned behavior to promote fruit and vegetable intake among schoolchildren: PROFRUVE study protocol
(Biomed Central, 2018-07-04)
Background: The PROFRUVE study is a controlled intervention based on the Theory of Planned Behavior (TPB), which follows those behavioral theories that have proved to be the most effective at changing infant fruit and ...
Changes in lipids and formation of derived compounds during fish cooking and in vitro gastrointestinal digestion of edible oils, model systems and processed fish meat
(2017-03-07)
En la presente tesis doctoral se plantearon cuatro objetivos principales. En el primer objetivo, se estudiaron los cambios provocados por el proceso de cocinado en los lípidos y/o perfil volátil del pescado mediante ...
Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
(Elsevier, 2019-03)
Background: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 ...
Biofunctionalization of alginate microcapsules: advances in cell-based drug delivery systems
(2015-09-16)
En la tesis titulada Biofunctionalization of alginate microcapsules: advances in cell-based drug delivery systems se han realizado tres trajajos experimentales basados en microcápsulas de alginato modificadas con diferentes ...
Utilización de la granulación por fusión en la obtención de comprimidos matriciales de liberación modificada
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitateko Argitalpen Zerbitzua, 2014-05-07)
Este trabajo recoge la aplicación de un proceso de granulación por fusíón en un solo paso para el desarrollo de comprimidos de liberación modificada de teofilina y lovastatina. En primer lugar, se realizó la caracterización ...
Intranasal Delivery of Plasma and Platelet Growth Factors Using PRGF-Endoret System Enhances Neurogenesis in a Mouse Model of Alzheimer’s Disease
(PLoS ONE, 2013-09-19)
[EN] Neurodegeneration together with a reduction in neurogenesis are cardinal features of Alzheimer’s disease (AD) induced by a combination of toxic amyloid-β peptide (Aβ) and a loss of trophic factor support. Amelioration ...
MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing
(MDPI, 2019-04-18)
Gene silencing targeting proangiogenic factors have been shown to be a useful strategy in the treatment of corneal neovascularization (CNV). Among interference RNA (RNAi) molecules, short-hairpin RNA (shRNA) is a plasmid-coded ...
Valoración de subproductos de la industria alimentaria mediante fermentación sólida y sumergida con Rhizopus sp.
(2019-03-03)
Se estima que entre un 20 y un 30 % del total de alimentos producidos en Europa se pierde o desperdicia, generando impactos negativos en toda la cadena de suministro de alimentos con unos costes asociados alrededor de 143 ...