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Diseño de un vector no viral basado en nanopartículas lipídicas para el tratamiento de la hepatitis C mediante ARN de interferencia
(2016-05-05)
La hepatitis C sigue siendo hoy en día un problema de salud pública a nivel mundial. Se estima que hay 170 millones de personas infectadas por el virus de la hepatitis C (HCV, del inglés hepatitis C virus) en el mundo, con ...
Design,optimization and in vivo evaluation of non-viral vectors for gene therapy. Applications in ocular disorders
(2013-09-27)
[EN] Over the past few years and due to biotechnology development, gene therapy has emerged as a promising therapeutic tool because of the use of exogenous nucleic acids as active ingredients. These nucleic acids, i.e. ...
Nanostructured lipid carriers as vehicles for the delivery of poorly water-soluble drugs
(2013-05-28)
El objetivo de esta tesis ha sido el desarrollo de una formulación basada en NLCs para la administración de fármacos poco solubles, tanto por vía oral como por vía intravenosa. Para ello: 1. Se ha llevado a cabo la evaluación ...
Resveratrol and Pterostilbene, Two Analogue Phenolic Compounds, Affect Aquaglyceroporin Expression in a Different Manner in Adipose Tissue
(MDPI, 2018-09)
Aquaglyceroporins (AQPs) are transmembrane channels that mediate glycerol release and glycerol uptake. They are involved in fat metabolism, with implications in obesity. The aim was to determine whether the administration ...
Pterostilbene Reduces Liver Steatosis and Modifies Hepatic Fatty Acid Profile in Obese Rats
(MDPI, 2019-04-26)
Excessive fat accumulation within the liver is known as "simple hepatic steatosis", which is the most benign form of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to determine whether pterostilbene ...
Involvement of 5′AMP-Activated Protein Kinase (AMPK) in the Effects of Resveratrol on Liver Steatosis
(MDPI, 2018-11-05)
This review focuses on the role of 5'-activated protein kinase (AMPK) in the effects of resveratrol (RSV) and some RSV derivatives on hepatic steatosis. In vitro studies, performed in different hepatic cell models, have ...
Do the Effects of Resveratrol on Thermogenic and Oxidative Capacities in IBAT and Skeletal Muscle Depend on Feeding Conditions?
(MDPI, 2018-10-06)
The aim of this study was to compare the effects of mild energy restriction and resveratrol on thermogenic and oxidative capacity in interscapular brown adipose tissue (IBAT) and in skeletal muscle. Rats were fed a high-fat ...
Resveratrol-Induced Effects on Body Fat Differ Depending on Feeding Conditions
(MDPI, 2017-11-29)
Science constantly seeks to identify new molecules that could be used as dietary functional ingredients in the fight against obesity and its co-morbidities. Among them, polyphenols represent a group of molecules of increasing ...
Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
(MDPI, 2017-08-15)
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma ...
Are miRNA-103, miRNA-107 and miRNA-122 Involved in the Prevention of Liver Steatosis Induced by Resveratrol?
(MDPI, 2017-04)
The aim of the present study was to determine whether the reduction in liver fat previously observed in our laboratory in a cohort of rats which had been fed an obesogenic diet was mediated by changes in the expression of ...