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Blocking ATP signaling and ROS generation preserves neurogenesis and network activity In epileptogenesis In hippocampal organotypic slice cultures.
(2024-01-26)
Epilepsy is a common neurological disorder, which lacks a comprehensive understanding of epileptogenesis. Temporal lobe epilepsy (TLE) in particular, often involves the hippocampus, with gliosis and abnormal neurogenesis. ...
The effect of omega-3 fatty acids on alcohol-induced damage
(Frontiers Media, 2023-04)
Alcohol is the most widely consumed psychoactive substance in the world that has a severe impact on many organs and bodily systems, particularly the liver and nervous system. Alcohol use during pregnancy roots long-lasting ...
Violence in first-episode psychosis: evidence from an early intervention in psychosis programme
(Cambridge University Press, 2023-09)
Background
Psychotic disorders are frequently associated with a public perception of dangerousness and belligerence. This situation has contributed to the social stigmatisation of people with severe mental illness and ...
Role of MCSF-activated microglia in amyloid-associated pathology
(2022-04-01)
Un evento clave que se desarrolla de forma temprana en la enfermedad de Alzheimer (EA) es el acúmulode las formas oligoméricas del péptido ß-amiloide (oAß) en el cerebro. En este estudio, hemosinvestigado el papel de la ...
A validated WAIS-IV short-form to estimate intellectual functioning in myotonic dystrophy type 1
(Elsevier, 2022-09)
Currently, no rapid and specific instrument is available to briefly estimate intelligence in patients with myotonic dystrophy type 1 (DM1), a multisystemic disease that involves the CNS and is associated with cognitive ...
Plasma and serum alpha-synuclein as a biomarker in Parkinson's disease: A meta-analysis
(Elsevier, 2022-06)
Background
Reliable biomarkers for Parkinson's disease (PD) diagnosis are urgently needed. Alpha-synuclein (α-syn) and its proteoforms play a key role in PD pathology but in vivo measurements have raised conflicting ...
Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease
(Springer Nature, 2023)
Background
Cognitive decline has been reported in premanifest and manifest Huntington’s disease but reliable biomarkers are lacking. Inner retinal layer thickness seems to be a good biomarker of cognition in other ...
Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
(Springer Nature, 2023)
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including ...
Estrategias no farmacológicas en el manejo de la violencia auto y heterodirigida en personas con trastorno mental grave.
(2022-04-08)
La violencia auto o heterodirigida en salud mental es un problema para el sistema sanitario no por su frecuencia sino por la gravedad de sus posibles consecuencias para el paciente y/o su entorno. Se considera necesario ...
Ejercicio físico combinado en personas con esquizofrenia: estudio Cortex-SP
(2024-02-01)
Objetivos: los objetivos principales de esta tesis doctoral en personas con esquizofrenia (SZ) fueron: 1) determinar algunos marcadores físicos, fisiológicos y bioquímicos clave del estado de salud, incluida la calidad del ...