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Now showing items 21-30 of 81
Estudio de la diversidad y estabilidad de diferentes priones recombinantes infecciosos para dilucidar los mecanismos moleculares que rigen el fenómeno de cepa
(2021-05-28)
Los priones son agentes infecciosos causantes de las encefalopatías espongiformes transmisibles (EET), un conjunto de enfermedades neurodegenerativas mortales. La teoría más aceptada propone que la PrPSc (isoforma patogénica ...
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
(2021-03)
Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive ...
Secondary Impacts of COVID-19 Pandemic in Fatigue, Self-Compassion, Physical and Mental Health of People with Multiple Sclerosis and Caregivers: The Teruel Study
(MDPI, 2021-09-18)
The secondary impacts of the COVID-19 pandemic are distress triggers and risk factors for mental health. Conversely, self-compassion skills and compassionate thoughts/behaviors towards suffering may contribute to their ...
Lifestyle-dependent microglial plasticity: training the brain guardians
(BMC, 2021-08-03)
Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All ...
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain
(Springer Nature, 2021-03-10)
The mechanisms responsible for determining neural stem cell fate are numerous and complex. To begin to identify the specific components involved in these processes, we generated several mouse neural stem cell (NSC) antibodies ...
Quantifying Knowledge of Alzheimer's Disease: an Analysis of the Psychometric Properties of the Alzheimer's Disease Knowledge Scale
(Springer, 2021-06)
Introduction: The Alzheimer's Disease Knowledge Scale (ADKS) is one of the most popular instruments for assessing a person's knowledge regarding Alzheimer's disease (AD). The objective of this study was to explore ADKS ...
Revisiones sistemáticas y meta-análisis en modelos animales para la investigación traslacional de patologías psiquiátricas.
(2021-09-16)
El trabajo se centra en el estudio de la eficacia de antinflamatorios en modelos animales de depresión como acercamiento a la investigación traslacional en su posible aplicación como intervención terapéutica en depresión. ...
Generación de distintas cepas de priones recombinantes como herramienta para el estudio del alplegamiento espontáneo en las enfermedades priónicas
(2021-09-17)
La isoforma malplegada (PrPSc) de la proteína del prion celular (PrPC), es el agente causal de las Encefalopatías Espongiformes Transmisibles (EET), un conjunto de desórdenes neurodegenerativos mortales que afectan a ...
Ultrastructural and physiological studies on the cannabinoid CB1 receptor localized in astroglia.
(2021-10-28)
The cannabinoid CB1 receptor-mediated functions in astrocytes are highly dependent on the CB1 receptor
distribution in these glial cells relative to neuronal sites, particularly at the nearby synapses under normal
or ...
Suicidal behaviour and cognition: A systematic review with special focus on prefrontal deficits
(Elsevier, 2021-01-01)
BACKGROUND: Suicide is a major health concern worldwide, thus, identifying risk factors would enable a more comprehensive understanding and prevention of this behaviour. Neuropsychological alterations could lead to ...