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The Spanish version of the reflective functioning questionnaire: Validity data in the general population and individuals with personality disorders.
(Public Library Science, 2023-04)
Introduction
Mentalization or reflective functioning (RF) is the capacity to interpret oneself or the others in terms of internal mental states. Its failures have been linked to several mental disorders and interventions ...
Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy
(Society for Neuroscience, 2023-04)
Therapeutic hypothermia is well established as a standard treatment for infants with hypoxic-ischemic (HI) encephalopathy but it is only partially effective. The potential for combination treatments to augment hypothermic ...
Identifying alterations in RNA metabolism and translation dynamics of oligodendrocytes in Alzheimer's disease
(2023-04-03)
La degeneración de la mielina y la pérdida de sustancia blanca son eventos tempranos en la enfermedad de Alzheimer (EA) que conducen a déficits cognitivos. Uno de los rasgos distintivos de la EA es la presencia de agregados ...
Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50–60 nm) Nanoparticles
(Springer, 2023-01)
Neuropathic pain is associated with abnormal sensations and/or pain induced by non-painful stimuli, i.e., allodynia causing burning or cold sensation, pinching of pins and needles like feeling, numbness, aching or itching. ...
Mortality Risks after Two Years in Frail and Pre-Frail Older Adults Admitted to Hospital
(MDPI, 2023-04-24)
Background: Frailty is characterized by a progressive decline in the physiological functions of multiple body systems that lead to a more vulnerable condition, which is prone to the development of various adverse events, ...
Evaluación del efecto de la regulación de la ruta de Wnt y mTOR en la distrofia muscular de cinturas R1 asociada a calpaína 3
(2023-07-17)
La distrofia muscular de cinturas R1 asociada a calpaína 3 (LGMDR1) o calpainopatía, es una distrofia muscular con herencia autosómico recesiva causada por mutaciones del gen CAPN3. El presente trabajo de investigación ...
Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies
(Taylor & Francis, 2023-02)
Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in ...
Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
(Wiley, 2023-01)
The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in late 1980s paved the way for investigations on the effects of cannabis-based ...
Local diffusion in the extracellular space of the brain
(Elsevier, 2023-02)
The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological complexity, composed of narrow gaps separated by local expansions, enabling interconnected highways between neural cells. ...
Neurocognition and functioning in adolescents at clinical high risk for psychosis
(BMC, 2023-02)
BACKGROUND: Once psychosis has set in, it is difficult for patients to achieve full recovery. Prevention of psychosis and early intervention are promising for improving the outcomes of this disorder. In the last two decades, ...