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Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum
(MDPI, 2019-04-14)
The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention ...
Empleo de CLEAs magnéticas de CALB para la obtención de biodiésel a partir de lípidos de microalgas
(2017-06-29)
La continua dependencia de los combustibles fósiles como fuente de energía ha afectado a nuestro medio ambiente dando lugar al fenómeno del calentamiento global. Una alternativa sostenible y renovable a éstos es el empleo ...
Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA
(Nature Publishing, 2016-03)
The biosynthesis of phospholipids and glycolipids are critical pathways for virtually all cell membranes. PatA is an essential membrane associated acyltransferase involved in the biosynthesis of mycobacterial phosphatidy ...
Desarrollo de líneas celulares competentes para la replicación de priones humanos mediante la reprogramación de fibroblastos de pacientes genéticamente susceptibles
(2016-07-05)
Las enfermedades espongiformes transmisibles (EETs) o enfermedades priónicas son un grupo de enfermedades neurodegenerativas mortales que afectan a seres humanos y animales, son producidas por el mal plegamiento de la ...
Creating stable Floquet–Weyl semimetals by laser-driving of 3D Dirac materials
(Nature Publishing, 2017-01-17)
Tuning and stabilizing topological states, such as Weyl semimetals, Dirac semimetals or topological insulators, is emerging as one of the major topics in materials science. Periodic driving of many-body systems offers a ...
Metabolic alterations in prostate cancer pathogenesis
(2016-09-16)
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs thatsustain cell growth, proliferation and promote cancer initiation and progression. In this thesis workwe describe a novel molecular mechanism ...
Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species
(Nature Publishing, 2017-11-13)
Antimicrobial peptides as part of the mammalian innate immune system target and remove major bacterial pathogens, often through irreversible damage of their cellular membranes. To explore the mechanism by which the important ...
Physical principles underlying structure, mechanics and dynamic re-organization of hyaluronan-rich matrices - from tissues to supramolecular models in experiment and theory
(2016-07-29)
The goal of this research project is to understand the physical principles that underlie the structure, mechanics and dynamic reorganization of hyaluronan-rich pericellular and extracellular matrices. Many cells produce a ...
Structural basis of glycogen biosynthesis regulation in bacteria
(2017-09-26)
ADP-glucosa pirofosforilasa (AGPasa) es la enzyma responsable de la formación de ADP-glucosa, reacción limitante en la biosíntesis de glucógeno en bacterias y almidón en plantas, y su actividad se encuentra regulada ...
What to consider when pseudohypoparathyroidism is ruled out: iPPSD and differential diagnosis
(Biomed Central, 2018-03-02)
Background: Pseudohypoparathyroidism (PHP) is a rare disease whose phenotypic features are rather difficult to identify in some cases. Thus, although these patients may present with the Albright's hereditary osteodystrophy ...