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Characterization of USP11 as a novel regulator of Hypoxia inducible factor a
(2019-11-27)
Adaptation to hypoxia is a puzzling and tightly regulated challenge. This adaptability involves a severe gene expression rewiring, which is mainly triggered by the Hypoxia Inducible transcription Factor (HIF). Canonically, ...
Molecular recognition between PCNA and proteins involved in DNA replication and repair: p15 and p12
(2019-12-19)
El antígeno nuclear de células en proliferación (PCNA) es un factor esencial en replicación y reparación de ADN en eucariotas. Forma un anillo homotrimérico que rodea y se desliza a lo largo del ADN, actuando como una ...
Targeting PML in triple negative breast cancer elicits growth suppression and senescence
(Nature, 2020-04)
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a ...
Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media
(Wiley, 2020-04)
The composition and intercellular interactions of tumor cells in the tissues dictate the biochemical and metabolic properties of the tumor microenvironment. The metabolic rewiring has a profound impact on the properties ...
Contextualization of the Bioeconomy Concept through Its Links with Related Concepts and the Challenges Facing Humanity
(MDPI, 2021-07-12)
The concept of bioeconomy is a topic of debate, confusion, skepticism, and criticism. Paradoxically, this is not necessarily a negative thing as it is encouraging a fruitful exchange of information, ideas, knowledge, and ...
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
(Nature, 2020-08-20)
Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused ...
Structural study of CUG-repeating small RNAs complexed with silencing suppressor P19
(2014-02-24)
The study is focused on structural aspects of interaction between silencing suppressor p19 and CUG-repeating small RNAs. The work involves crystal structure determination of a protein-unbound RNA form and RNA fragments of ...
Magnetic Cross-Linked Enzyme Aggregates (mCLEAs) of Candida antarctica Lipase: An Efficient and Stable Biocatalyst for Biodiesel Synthesis
(Public Library Science, 2014-12-31)
Enzyme-catalyzed production of biodiesel is the object of extensive research due to the global shortage of fossil fuels and increased environmental concerns. Herein we report the preparation and main characteristics of a ...
Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
(Oxford University Press, 2008-08)
Linker histone H1 plays an important role in chromatin folding. Phosphorylation by cyclin-dependent kinases is the main post-translational modification of histone H1. We studied the effects of phosphorylation on the secondary ...
Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus
(Public Library of Science, 2013-01-03)
The biosynthesis of membrane lipids is an essential pathway for virtually all bacteria. Despite its potential importance for the development of novel antibiotics, little is known about the underlying signaling mechanisms ...