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Nanostructured lipid carriers for nose-to-brain delivery in neurodegenerative diseases therapy
(2016-03-10)
El objetivo principal de esta Tesis Doctoral es el desarrollo de partículas lipídicas nanoestructuradas (NLC) como vehículo para promover la liberación de factores neurotróficos al cerebro, tras su administración intranasal ...
Characterization of edible oils main and minor components and study of their evolution during oxidation, nixtamalization and in vitro digestion processes by non-conventional tecniques DI-SPME-GC/MS and1H NMR spectroscopy
(2020-07-27)
En la presente tesis doctoral, por un lado, se abordó el estudio de la caracterización de aceites vegetales de diferente origen botánico, prestando atención a su composición en componentes minoritarios mediante el empleo ...
Impact of Augmented Renal Clearance in Critically Ill Patients: Population Pharmacokinetics of Levetiracetam and Dosing Evaluation
(2022-06-27)
Introduction: Augmented renal clearance (ARC) is a phenomenon recently identified in critically ill patients.ARC has the potential to influence the pharmacokinetic profile of any drug that is renally cleared andknown to ...
Perfil aromático de los quesos Palmero y Herreño y estudio de su grado de contaminación por hidrocarburos aromáticos policíclicos
(2016-02-01)
En esta memoria se ha abordado el estudio de los componentes que forman parte del perfil aromático de quesos Palmeros artesanales ahumados y quesos Herreños ahumados así como la presencia de HAPs en los mismos, ya que como ...
Study of the In Vitro Digestion of Olive Oil Enriched or Not with Antioxidant Phenolic Compounds. Relationships between Bioaccessibility of Main Components of Different Oils and Their Composition
(MDPI, 2020-06-20)
The changes provoked by in vitro digestion in the lipids of olive oil enriched or not with different phenolic compounds were studied by proton nuclear magnetic resonance (1H NMR) and solid phase microextraction followed ...
Development of novel therapeutic approaches to promote the healing of chronic wounds
(2018-12-04)
En esta tesis se han desarrollado diferentes formulaciones terapéuticas para la cicatrización de heridas crónicas, ya que éstas son una patología en auge, por el gran aumento de los factores que participan en la cronificación ...
A Global Study by 1H NMR Spectroscopy and SPME-GC/MS of the in Vitro Digestion of Virgin Flaxseed Oil Enriched or not with Mono-, Di- or Tri-Phenolic Derivatives. Antioxidant Efficiency of These Compounds
(MDPI, 2020-04-15)
The effect of enriching virgin flaxseed oil with dodecyl gallate, hydroxytyrosol acetate or gamma-tocopherol on its in vitro digestion is studied by means of proton nuclear magnetic resonance and solid phase microextraction ...
Key Aspects in Nutritional Management of COVID-19 Patients
(MDPI, 2020-08-10)
This review deals with the relationship among nutrition, the immune system, and coronavirus disease 2019 (COVID-19). The influence of nutrients and bioactive molecules present in foodstuffs on immune system activity, the ...
The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
(MDPI, 2021-06-03)
Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to establish rational dosage regimens of antimicrobial agents in human and veterinary medicine. Actually, PK/PD studies are included in the ...
Association of Breakfast Quality and Energy Density with Cardiometabolic Risk Factors in Overweight/Obese Children: Role of Physical Activity
(MDPI, 2018-08)
There is a general belief that having breakfast is an important healthy lifestyle factor; however, there is scarce evidence on the influence of breakfast quality and energy density on cardiometabolic risk in children, as ...