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Regulation of cell growth, survival and migration by ceramide 1-phosphate - implications in lung cancer progression and inflammation
(Elsevier, 2021-07)
Ceramide 1-phosphate (C1P) is a bioactive sphingolipid that is implicated in the regulation of vital cellular functions and plays key roles in a number of inflammation-associated pathologies. C1P was first described as ...
Sphingomyelin: What is it good for?
(Elsevier, 2022-12)
Sphingomyelin has been considered as a merely structural lipid for many years. However, this organelle-specific lipid has many other roles, including increasing membrane molecular order, acting as a source of ceramide in ...
Systematic review of the potential of MicroRNAs in the management of patients with follicular lymphoma
(Elsevier, 2021-03)
Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma and usually presents as an indolent disease. However, some patients present poor outcomes, and FL can transform into more aggressive lymphomas, such ...
Development of a high-throughput platform to measure plasmid transfer frequency
(Frontiers Media, 2023-10)
Antibiotic resistance represents one of the greatest threats to global health. The spread of antibiotic resistance genes among bacteria occurs mostly through horizontal gene transfer via conjugation mediated by plasmids. ...
Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane
(Nature, 2023-11)
Bacterial competition is a significant driver of toxin polymorphism, which allows continual compensatory evolution between toxins and the resistance developed to overcome their activity. Bacterial Rearrangement hot spot ...
The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
(Nature, 2022)
The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to ...
Conformational Plasticity Underlies Membrane Fusion Induced by an HIV Sequence Juxtaposed to the Lipid Envelope
(Springer Nature, 2021-01-14)
Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes of target cells upon activation of the virus-cell fusion reaction. ...
Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain
(MDPI, 2021-06-11)
APE1 (DNA (apurinic/apyrimidinic site) endonuclease 1) is a key enzyme of one of the major DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions, acting as a redox regulator of ...
Effects of a N-Maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers
(MDPI, 2023-11-21)
<i>N</i>-maleimide-derivatized phospholipids are often used to facilitate protein anchoring to membranes. In autophagy studies, this is applied to the covalent binding of Atg8, an autophagy protein, to a phosphatidylethanolamine ...
Genetics and Epigenetics in Complex Diseases
(MDPI, 2023-05-03)