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dc.contributor.authorGonzález Pinto Arrillaga, Ana María ORCID
dc.contributor.authorMartínez Cengotitabengoa, Mónica ORCID
dc.contributor.authorArango, Celso
dc.contributor.authorBaeza, Inmaculada
dc.contributor.authorOtero Cuesta, Soraya
dc.contributor.authorGraell Berna, Montserrat
dc.contributor.authorSoutullo, César
dc.contributor.authorLeza, Juan Carlos
dc.contributor.authorMicó, Juan Antonio
dc.date.accessioned2013-05-20T17:57:11Z
dc.date.available2013-05-20T17:57:11Z
dc.date.issued2012-11-16
dc.identifier.citationBMC Psychiatry 12(200) : (2012)es
dc.identifier.issn1471-244X
dc.identifier.urihttp://hdl.handle.net/10810/10136
dc.description.abstract[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with familiar environment measured using the Family Environment Scale (FES). Methods: We included 82 HC and 14 HC-FHP aged between 9 and 17 years. Total antioxidant status,lipid peroxidation, antioxidant enzyme activities and glutathione levels were determined in blood samples. Results:There was a significant decrease in the total antioxidant level in the HC-FHP group compared with the HC group (OR = 2.94; p = 0.009), but no between-group differences in the Global Assessment of Functioning (GAF) scale scores. For the FES, the HC-FHP group had significantly higher scores in the cohesion (p = 0.007) and intellectual-cultural dimensions (p=0.025). After adjusting for these two FES dimensions, total antioxidant status remained significantly different between groups (OR = 10.86, p = 0.009).es
dc.language.isoenges
dc.publisherBioMed Centrales
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectoxidative stresses
dc.subjectfamily environmentes
dc.subjectpsychosises
dc.subjectschizophreniaes
dc.subjectantioxidant enzymeses
dc.titleAntioxidant defense system and family environment in adolescents with family history of psychosises
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2012 Gonzalez-Pinto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es
dc.relation.publisherversionhttp://www.biomedcentral.com/1471-244X/12/200es
dc.identifier.doi10.1186/1471-244X-12-200
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES
dc.subject.categoriaPSYCHIATRY AND MENTAL HEALTH


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