dc.contributor.author | Ruiz de Azúa García, Sonia | |
dc.contributor.author | Matute Almau, Carlos José | |
dc.contributor.author | Stertz, Laura | |
dc.contributor.author | Mosquera, Fernando | |
dc.contributor.author | Palomino Fernández de Larrea, Aitor | |
dc.contributor.author | De la Rosa, Iris | |
dc.contributor.author | Barbeito, Sara | |
dc.contributor.author | Vega, Patricia | |
dc.contributor.author | Kapczinski, Flavío | |
dc.contributor.author | González Pinto Arrillaga, Ana María | |
dc.date.accessioned | 2013-05-28T11:48:23Z | |
dc.date.available | 2013-05-28T11:48:23Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | BMC Psychiatry (13)27 : (2013) | es |
dc.identifier.issn | 1471-244X | |
dc.identifier.uri | http://hdl.handle.net/10810/10162 | |
dc.description.abstract | Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether
Brain Derived Neurotrophic Factor (BDNF) levels are associated with cognitive impairment in FEP patients compared
with healthy controls.
Methods: 45 FEP patients and 45 healthy controls matched by age, gender and educational level were selected
from the Basque Country area of Spain. Plasma BDNF levels were assessed in healthy controls and in patients. A battery of cognitive tests was applied to both groups, with the patients being assessed at 6 months after the acute episode and only in those with a clinical response to treatment.
Results: Plasma BDNF levels were altered in patients compared with the control group. In FEP patients, we observed a positive association between BDNF levels at six months and five cognitive domains (learning ability,immediate and delayed memory, abstract thinking and processing speed) which persisted after controlling for
medications prescribed, drug use, intelligence quotient (IQ) and negative symptoms. In the healthy control group,
BDNF levels were not associated with cognitive test scores.
Conclusion: Our results suggest that BDNF is associated with the cognitive impairment seen after a FEP. Further investigations of the role of this neurotrophin in the symptoms associated with psychosis onset are warranted. | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | psychotic disorder | es |
dc.subject | brain-derived neurotrophic factor | es |
dc.subject | schizophrenia | es |
dc.subject | cognition | es |
dc.title | Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2013 Ruiz de Azua et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es |
dc.relation.publisherversion | http://www.biomedcentral.com/1471-244X/13/27 | es |
dc.identifier.doi | 10.1186/1471-244X-13-27 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |
dc.subject.categoria | PSYCHIATRY AND MENTAL HEALTH | |