Browsing OpenAire by Author "Pamplona, Reinald"
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Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
Prieto, Ignacio; Rubio Alarcón, Carmen; García Gómez, Raquel; Berdún, Rebeca; Urgel, Tamara; Portero, Manuel; Pamplona, Reinald; Martínez Ruiz, Antonio; Ruiz Sanz, José Ignacio; Ruiz Larrea, María Begoña ; Jove, Mariona; Cerdán, Sebastián; Monsalve, María (Elsevier, 2020-01)PGC-1 alpha controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ...