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dc.contributor.authorPiedrafita, Gabriel
dc.contributor.authorRuiz Mirazo, Pedro
dc.contributor.authorMonnard, Pierre-Alain
dc.contributor.authorCornish-Bowden, Athel
dc.contributor.authorMontero, Francisco
dc.date.accessioned2014-02-19T17:24:05Z
dc.date.available2014-02-19T17:24:05Z
dc.date.issued2012-06
dc.identifier.citationPLoS One 7(6) : (2012) // e39480es
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10810/11570
dc.description.abstractIn this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions under which a reaction network with a catalytically closed organization (more specifically, an (M, R)-system) would overcome the potential problem of self-suffocation that arises from the limited accessibility of nutrients to its internal reaction domain. The relationship between the permeability of the membrane, the lifetime of the key catalysts and their efficiency (reaction rate enhancement) turns out to be critical. In particular, we show how permeability values constrain the characteristic time scale of the bounded protometabolic processes. From this concrete and illustrative example we finally extend the discussion to a wider evolutionary context.es
dc.description.sponsorshipThis work was partially supported by the research projects BFU2009-12895-C02-02 and FFI2011-25665 (Ministerio de Economia y Competitividad, Spain). KRM also acknowledges support by grant IT 505-10 (Gobierno Vasco, Spain). PAM acknowledges support by the Danish National Research Foundation and by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement 249032. GP holds a FPU PhD scholarship (Ministerio de Educacion, Cultura y Deporte, Spain).es
dc.language.isoenges
dc.publisherPublic Library Sciencees
dc.relationinfo:eu-repo/grantAgreement/MICINN/BFU2009-12895-C02-02
dc.relationinfo:eu-repo/grantAgreement/MINECO/FFI2011-25665
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectmetabolic closurees
dc.subjectlipid vesicleses
dc.subjectlifees
dc.subjectmodeles
dc.subjectevolutiones
dc.subjectmembraneses
dc.subjectoriginses
dc.subjectcellses
dc.subjectoligomerizationes
dc.subjectamphiphileses
dc.titleViability Conditions for a Compartmentalized Protometabolic System: A Semi-Empirical Approaches
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2012 Piedrafita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039480es
dc.identifier.doi10.1371/journal.pone.0039480
dc.departamentoesLógica y filosofía de la cienciaes_ES
dc.departamentoeuLogika eta zientziaren filosofiaes_ES
dc.subject.categoriaAGRICULTURAL AND BIOLOGICAL SCIENCES
dc.subject.categoriaMEDICINE
dc.subject.categoriaBIOCHEMISTRY AND MOLECULAR BIOLOGY


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