dc.contributor.author | Piedrafita, Gabriel | |
dc.contributor.author | Ruiz Mirazo, Pedro | |
dc.contributor.author | Monnard, Pierre-Alain | |
dc.contributor.author | Cornish-Bowden, Athel | |
dc.contributor.author | Montero, Francisco | |
dc.date.accessioned | 2014-02-19T17:24:05Z | |
dc.date.available | 2014-02-19T17:24:05Z | |
dc.date.issued | 2012-06 | |
dc.identifier.citation | PLoS One 7(6) : (2012) // e39480 | es |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/11570 | |
dc.description.abstract | In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions under which a reaction network with a catalytically closed organization (more specifically, an (M, R)-system) would overcome the potential problem of self-suffocation that arises from the limited accessibility of nutrients to its internal reaction domain. The relationship between the permeability of the membrane, the lifetime of the key catalysts and their efficiency (reaction rate enhancement) turns out to be critical. In particular, we show how permeability values constrain the characteristic time scale of the bounded protometabolic processes. From this concrete and illustrative example we finally extend the discussion to a wider evolutionary context. | es |
dc.description.sponsorship | This work was partially supported by the research projects BFU2009-12895-C02-02 and FFI2011-25665 (Ministerio de Economia y Competitividad, Spain). KRM also acknowledges support by grant IT 505-10 (Gobierno Vasco, Spain). PAM acknowledges support by the Danish National Research Foundation and by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement 249032. GP holds a FPU PhD scholarship (Ministerio de Educacion, Cultura y Deporte, Spain). | es |
dc.language.iso | eng | es |
dc.publisher | Public Library Science | es |
dc.relation | info:eu-repo/grantAgreement/MICINN/BFU2009-12895-C02-02 | |
dc.relation | info:eu-repo/grantAgreement/MINECO/FFI2011-25665 | |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | metabolic closure | es |
dc.subject | lipid vesicles | es |
dc.subject | life | es |
dc.subject | model | es |
dc.subject | evolution | es |
dc.subject | membranes | es |
dc.subject | origins | es |
dc.subject | cells | es |
dc.subject | oligomerization | es |
dc.subject | amphiphiles | es |
dc.title | Viability Conditions for a Compartmentalized Protometabolic System: A Semi-Empirical Approach | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2012 Piedrafita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | es |
dc.relation.publisherversion | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039480 | es |
dc.identifier.doi | 10.1371/journal.pone.0039480 | |
dc.departamentoes | Lógica y filosofía de la ciencia | es_ES |
dc.departamentoeu | Logika eta zientziaren filosofia | es_ES |
dc.subject.categoria | AGRICULTURAL AND BIOLOGICAL SCIENCES | |
dc.subject.categoria | MEDICINE | |
dc.subject.categoria | BIOCHEMISTRY AND MOLECULAR BIOLOGY | |