dc.contributor.author | Tucci, Francesca | |
dc.contributor.author | Astarita, Luca | |
dc.contributor.author | Abkari, Abdelhak | |
dc.contributor.author | Abu-Zekry, Mona | |
dc.contributor.author | Attard, Thomas | |
dc.contributor.author | Ben Hariz, Mongi | |
dc.contributor.author | Bilbao Catalá, José Ramón | |
dc.contributor.author | Boudraa, Ghazalia | |
dc.contributor.author | Boukthir, Samir | |
dc.contributor.author | Costa, Stefano | |
dc.contributor.author | Djurisic, Veselinka | |
dc.contributor.author | Hugot, Jean-Pierre | |
dc.contributor.author | Irastorza Terradillos, Iñaki Xarles | |
dc.contributor.author | Kansu, Aydan | |
dc.contributor.author | Kolacek, Sanja | |
dc.contributor.author | Magazzu, Giuseppe | |
dc.contributor.author | Micetic-Turk, Dusanka | |
dc.contributor.author | Misak, Zrinjka | |
dc.contributor.author | Roma, Eleftheria | |
dc.contributor.author | Rossi, Pasqualino | |
dc.contributor.author | Terzic, Selma | |
dc.contributor.author | Velmishi, Virtut | |
dc.contributor.author | Arcidiaco, Carmela | |
dc.contributor.author | Auricchio, Renata | |
dc.contributor.author | Greco, Luigi; | |
dc.date.accessioned | 2014-03-28T17:09:37Z | |
dc.date.available | 2014-03-28T17:09:37Z | |
dc.date.issued | 2014-02 | |
dc.identifier.citation | Bmc Gastroenterology 14 : (2014) // Article 24 | es |
dc.identifier.issn | 1471-230X | |
dc.identifier.uri | http://hdl.handle.net/10810/11861 | |
dc.description.abstract | Background: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since a new ESPGHAN diagnostic protocol was recently published, our secondary aim is to estimate how many cases in the same area could be identified without a small intestinal biopsy.
Methods: By a stratified cross-sectional retrospective study design, we examined clinical, histological and laboratory data from 749 consecutive unselected CD children diagnosed by national referral centers.
Results: The vast majority of cases were diagnosed before the age of 10 (median: 5 years), affected by diarrhea, weight loss and food refusal, as expected. Only 59 cases (7.8%) did not suffer of major complaints. Tissue transglutaminase (tTG) assay was available, but one-third of centers reported financial constraints in the regular purchase of the assay kits. 252 cases (33.6%) showed tTG values over 10 times the local normal limit. Endomysial antibodies and HLA typing were routinely available in only half of the centers. CD was mainly diagnosed from small intestinal biopsy, available in all centers. Based on these data, only 154/749 cases (20.5%) would have qualified for a diagnosis of CD without a small intestinal biopsy, according to the new ESPGHAN protocol.
Conclusions: This cross-sectional study of CD in the Mediterranean referral centers offers a puzzling picture of the capacities to deal with the emerging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organization guidelines. | es |
dc.description.sponsorship | Sponsored by the Ministery of Health of Italy, Direction of International Affairs; Euromed (Episouth) action. Project: "Food-induced diseases - Celiac Disease (Medicel) - Phase II" (CUP no E61J11000450001) | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | mediterranean area | es |
dc.subject | celiac disease | es |
dc.subject | world gastroenterology organization | es |
dc.subject | ESPGHAN guidelines | es |
dc.title | Celiac disease in the Mediterranean area | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2014 Tucci et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | es |
dc.relation.publisherversion | http://www.biomedcentral.com/1471-230X/14/24 | es |
dc.identifier.doi | 10.1186/1471-230X-14-24 | |
dc.departamentoes | Pediatría | es_ES |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Pediatria | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |
dc.subject.categoria | GASTROENTEROLOGY AND HEPATOLOGY | |