Browsing TD-Ciencias de la Vida by Title
Now showing items 719-738 of 820
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Sphingosine 1-phosphate (S1P) system in healthy brain and alzheimer's disease
(2021-01-27)The physiological consequences of the super-specialization of the lipids in the different regions and cellular types of the central nervous system (CNS), remain largely being a mystery. In fact, the so-called neurolipids, ... -
Streptococcus Pyogenes y otitis media aguda, una etiología frecuente
(2017-06-08)El objetivo de este trabajo consiste en conocer las características epidemiológicas, clínicas y audiológicas de los pacientes menores de 14 años con otitis media aguda a S. pyogenes.Se ha diseñado un trabajo en dos fases. ... -
Structural basis for substrate recognition and catalysis of the mycobacterial acyltransferase pata
(2018-02-22)Los glicolípidos desempeñan un papel central en una variedad de procesos biológicos importantes en todos los organismos vivos. PatA es una aciltransferasa asociada a la membrana implicada en la biosíntesis de fosfatidil- ... -
Structural basis of glycogen biosynthesis regulation in bacteria
(2017-09-26)ADP-glucosa pirofosforilasa (AGPasa) es la enzyma responsable de la formación de ADP-glucosa, reacción limitante en la biosíntesis de glucógeno en bacterias y almidón en plantas, y su actividad se encuentra regulada ... -
Structural characterization of helices A and B of Kv7.2 channel bound to Calmodulin. The calcium effect
(2015-12-15)Los canales neuronales heterodiméricos Kv7.2 y Kv7.3 son el sustrato molecular de la corriente depotasio no-inactivante dominada ¿Corriente M¿. Ésta juega un papel crítico en el control de laexcitabilidad neuronal. Su mal ... -
Structural studies of the hipersaline adaptation of proteins belonging to halophilic archaea
(2015-10-05)Adaptation of organisms to extreme halophilic environments (> 1 ¿ 2 M) occurs through theaccumulation of large intracellular concentrations of KCl. Their major adaptive feature is theextensive modification of the constituting ... -
Structural study of flavivirus immunomodulator proteins from AEDES AEGYPTI salivary glands.
(2023-02-23)Aedes aegypti bacteria-responsive protein 1 (AgBR1) y neutrophil stimulating factor 1 (NeSt1) son dos proteínas salivales del mosquito Aedes aegypti que actúan como potenciadoras de la infección del virus Zika (ZIKV). En ... -
Structure-function relationships of tumor suppresor ING5
(2017-07-04)La familia ING (INhibitor of Growth) de supresores tumorales está formada por cinco proteínas homólogas que regulan el estado transcripcional de la cromatina por medio del reclutamiento de complejos remodeladores de cromatina ... -
Studies on AUF1-regulated deubiquitinase complexes: USP1/UAF1, USP12/UAF1 and USP46/UAF1
(2017-07-05)Deubiquitinases (DUBs) regulate a wide range of cellular processes and are potential targets for cancer therapy. Our knowledge on the biology of these enzymes is still limited. We focused on three human DUBs (USP1, USP12 ... -
Study of Aspergillus fumigatus pathogenicity and identification of putative virulence genes
(2016-12-02)Aspergillus fumigatus is considered to be the most prevalent airborne pathogenic fungus. lts infection begins with conidial germination in lungs where different types of aspergillosis can be developed. In profoundly ... -
Study of human and mouse dermal fibroblast heterogeneity by single-cell RNA sequencing.
(2023-10-18)The skin is a complex vital organ composed of several layers. The middle layer, the dermis, is mainly composed of fibroblasts that produce the extracellular matrix (ECM) providing structural support. Recent research using ... -
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Study of the Aspergillus fumigatus host-pathogen interaction using transcriptomic techniques and mutant strains generation
(2021-03-26)Aspergillus fumigatus is a filamentous fungus capable to cause a wide range of diseases depending on the immune status of the patient who breath its conidia. The most dangerous disease caused by this fungus is known as ... -
Study of the distribution of nuclear basket-related nucleoporins after histone deacetylase inhibition.
(2021-07-14)El complejo del poro nuclear está constituido por proteínas denominadas nucleoporinas cuya función erasupuestamente restringida al transporte nucleocitoplasmático. Evidencias recientes, sugieren que lasnucleoporinas ... -
Study of the effect of candida albicans recombinant proteins and derived monoclonal antibodies on protumoral processes and as diagnostic and therapeutic tools.
(2018-10-04)Candida albicans is a human commensal yeast that can sometimes cause life-threatening infections, especially in immunocompromised patients. The high mortality rates associated with this fungus make necessary the study of ... -
Study of the epigenetic cellular memory induced by morphine: a next generation sequencing approach
(2019-09-09)Epigenetikak, kanpo faktoreek edo inguruneak norbanakoan izan dezaketen eragina aztertzen du. Azken urteetan, zenbait ikerketek erakutsi dutenez, inguruneak eragin zuzena izan dezake norbanako helduaren ezaugarri ... -
Study of the impact of hepatocytes-secreted extracellular vesicles in liver diseases
(2023-10-20)Las vesículas extracelulares (EVs) son pequeñas partículas delimitadas por membranas lipídicas que las células generan y secretan al espacio extracelular. Su función principal es facilitar la comunicación intracelular, y ... -
Study of the long-lasting effects of ethanol consumption during adolescence on cannabinoid type 1 receptor-dependent synaptic transmission and plasticity in dentate gyrus synapses.
(2018-10-17)El consumo excesivo de alcohol, especialmente durante la adolescencia, es una preocupación generalizada de salud pública. Investigaciones en la última década han puesto de manifiesto que el consumo de etanol (EtOH) y el ... -
Studying the role of E2F1 and E2F2 in the metabolism of nucleotides: therapeutic implications for the treatment of prostate cancer.
(2022-05-27)E2F-dependent transcriptional network ensures the timely entry of cells into S-phase through the regulation of a vast array of genes involved in DNA replication and cell cycle progression. In this Thesis, we aimed to ... -
SU-8 microprobes for biomedical applications
(2014-01-30)[ES]La presente tesis doctoral aborda el diseño, fabricación, encapsulado, y caracterización de microagujas de SU-8 para aplicaciones médicas. En la actualidad existe una amplia variedad de agujas para el registro, ...