Browsing Artículos, Comunicaciones, Libros by Author "IBARGUREN, MAITANE"
Now showing items 1-5 of 5
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Changes in Membrane Organization upon Spontaneous Insertion of 2‑Hydroxylated Unsaturated Fatty Acids in the Lipid Bilayer
Khmelinskaia, Alena; Ibarguren, Maitane ; de Almeida, Rodrigro F.M.; López Jiménez, David ; Paixao, Vanda A.; Ahyayauch, Hasna; Goñi Urcelay, Félix María ; Escriba, Pablo (American Chemical Society, 2014-02-03)Recent research regarding 2-hydroxylated fatty acids (2OHFAs) showed clear evidence of their benefits in the treatment of cancer, inflammation, and neurodegenerative disorders such as Alzheimer’s disease. Monolayer ... -
Imaging the early stages of phospholipase C/sphingomyelinase activity on vesicles containing coexisting order-disorder and gel-fluid domains
Ibarguren, Maitane ; López Jiménez, David ; Montes, L. Ruth; Sot, Jesus ; Vasil, Michael L.; Vasil, Adriana I.; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Elsevier, 2011-04)[EN] The binding and early stages of activity of a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa on giant unilamellar vesicles (GUV) have been monitored using fl uorescence confocal microscopy. Both the ... -
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease
Torres, Manuel; Price, Samantha L.; Fiol-deRoque, Maria Antonia; Marcilla-Etxenike, Amaia; Ahyayauch, Hasna; Barceló-Coblijn, Gwendolyn ; Terés, Silvia; Katsouri, Loukia; Ordinas, Margarita; López Jiménez, David ; Ibarguren, Maitane ; Goñi Urcelay, Félix María ; Busquets, Xavier ; Vitorica Ferrández, Javier; Sastre, Magdalena; Escriba, Pablo (Elsevier, 2013-12-27)[EN] Alzheimer's disease (AD) is a neurodegenerative pathology with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the omega-3 polyunsaturated fatty acid ... -
Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives
Ibarguren, Maitane ; López Jiménez, David ; Encinar Hidalgo, José Antonio; González-Ros, Jose Manuel; Busquets, Xavier ; Escriba, Pablo (2013-06-18)[EN] Cellular functions are usually associated with the activity of proteins and nucleic acids. Recent studies have shown that lipids modulate the localization and activity of key membrane-associated signal transduction ... -
The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes
Piotto, Stefano; Trapani, Alfonso; Bianchino, Erminia; Ibarguren, Maitane ; López Jiménez, David ; Busquets, Xavier ; Concilio, Simona (Elsevier B.V., 2014-01-24)The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) is an antitumor drug that regulates membrane lipid composition and structure. An important effect of this drug is the restoration of sphingomyelin (SM) levels in cancer ...