BackExaminar Artículos, Comunicaciones, Libros por departamento (eus.) "Farmakologia"
Now showing items 21-40 of 130
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Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping Out of the Striatum
(MDPI, 2019-08-29)The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate in a great variety of functions, ranging from motor programming and execution to procedural learning, cognition, and emotions. ... -
Cellular neurochemical characterization and subcellular localization of Phospholipase C-β1 in rat brain
; ; López de Jesús, Maider
; ; ; Barrondo Lacarra, Sergio ; (Elsevier, 2012-10-11)
The present study describes a complete and detailed neuroanatomical distribution map of the phospholipase C beta1 (PLCβ1) isoform along the adult rat neuraxis, and defines the phenotype of cells expressing PLCβ1, along ... -
Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers
Requejo Rodríguez, Catalina; ; ; Fernández Gómez de Segura, Elsa; Calvo Salomón, Pilar María; ; Miguélez Palomo, Cristina; Cardona Grifoll, Laura; Cepeda Berenguer, Hodei; ; Lafuente Sánchez, José Vicente (Frontiers Media, 2020-10-14)
The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ... -
Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
; ; ; ; Callado Hernando, Luis Felipe; Meana Martínez, José Javier ; Díez Alarcia, Rebeca (Springer, 2021-08)
Background: Alterations of dopamine D-1 (D1R) and D-2 receptor (D2R) are proposed in schizophrenia but brain neuroimaging and postmortem studies have shown controversial results in relation to D1R and D2R density. Besides, ... -
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
Fernández Fernández, Cristina; Callado Hernando, Luis Felipe; Girón, Rocío; Sánchez, Eva; Erdozain Fernández, Amaia Maite ; López-Moreno, José Antonio; Morales, Paula; Rodríguez de Fonseca, Fernando; Fernández-Ruiz, Javier; Goya, Pilar; Meana Martínez, José Javier ; Martín, Isabel; Jagerovic, Nadine (Dove Medical Press, 2014)
Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ... -
Current Techniques for Investigating the Brain Extracellular Space
Soria Lannes, Federico Nicolás; ; Peñagarikano Ahedo, Olga ; Tonnesen, Jan (Frontiers Media, 2020-10-14)
The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions ... -
Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain
Gil de la Pisa, Itziar; Cebrián, Carolina; Ortega Calvo, Jorge; Meana Martínez, José Javier; Sulzer, David (Biomed Central, 2014-07-29)
Background: An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ... -
D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
(Nature Publishing, 2018-06-11)Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement ... -
Decreased Striatal Adenosine A(2A)-Dopamine D(2)Receptor Heteromerization in Schizophrenia
Valle León, Marta; Callado Hernando, Luis Felipe; Aso, Ester; Cajiao Manrique, María del Mar; Sahlholm, Kristoffer; López Cano, Marc; Soler, Concepcio; Altafaj, Xavier; Watanabe, Masahiko; Ferre, Sergi; Fernández Dueñas, Víctor; Menchón, José Manuel; Ciruela, Francisco (Springer Nature, 2020-10-03)
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either be ... -
Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA
; ; Llamosas Muñozguren, Nerea; ; (Cell Press, 2015-08-11)
Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson's disease (PD) and psychiatric disorders. L-DOPA, the leading treatment of PD, facilitates ... -
Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell membranes: an alternative to radioligand binding methods
; ; ; ; Barrondo Lacarra, Sergio; López de Jesús, Maider ; ; ; Goicolea Altuna, María Aranzazu ; ; (BMC, 2022)
Background: Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards ... -
Di-aryl guanidinium derivatives: Towards improved α2-Adrenergic affinity and antagonist activity
McMullan, Michela; Kelly, Brendan; Mihigo, Helene B.; Keogh, Aaron P.; Rodríguez, Fernando; Brocos Mosquera, Iria; García Bea, Aintzane; Miranda Azpiazu, Patricia; Callado Hernando, Luis Felipe; Rozas, Isabel (Elsevier, 2021-01-01)
Compounds with excellent receptor engagement displaying alpha(2)-AR antagonist activity are useful not only for therapeutic purposes (e.g. antidepressants), but also to help in the crystallization of this particular GPCR. ... -
Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment
; ; Muguruza Millán, Carolina; ; ; Meana Martínez, José Javier ; Callado Hernando, Luis Felipe ; Rivero Calera, Guadalupe (Springer Nature, 2021-12-20)
[EN] Postsynaptic alpha(2A)-adrenoceptor density is enhanced in the dorsolateral prefrontal cortex (DLPFC) of antipsychotic-treated schizophrenia subjects. This alteration might be due to transcriptional activation, and ... -
Dopamine D4 Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum
(MDPI, 2021-12-23)Long-term exposition to morphine elicits structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, morphine-induced neuroadaptations in the dorsal striatum ... -
Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics
Ruso Julve, Fulgencio; Pombero, Ana; Pilar Cuéllar, Fuencisla; García Díaz, Nuria; Garcia López, Raquel; Juncal Ruiz, María; Castro, Elena; Díaz, Álvaro; Vazquez Bourgón, Javier; García Blanco, Agustín; Garro Martínez, Emilio; Pisonero, Helena; Estirado, Alicia; Ayesa Arriola, Rosa; López Giménez, Juan; Mayor, Federico; Valdizán, Elsa; Meana Martínez, José Javier; González Maeso, Javier; Martínez, Salvador; Vaqué, José Pedro; Crespo Facorro, Benedicto (Nature, 2019-11-18)
A better understanding of the molecular mechanisms that participate in the development and clinical manifestations of schizophrenia can lead to improve our ability to diagnose and treat this disease. Previous data strongly ... -
Dopaminergic Denervation Impairs Cortical Motor and Associative/Limbic Information Processing Through the Basal Ganglia and its Modulation by the CB1 Receptor
Antonazzo Soler, Mario; Gómez Urquijo, Sonia María ; ; (Academic Press, 2021-01)
The basal ganglia (BG) are involved in cognitive/motivational functions in addition to movement control. Thus, BG segregated circuits, the sensorimotor (SM) and medial prefrontal (mPF) circuits, process different functional ... -
Editorial: Non-Dopaminergic Systems in Parkinson's Disease
(Frontiers Media, 2020-09-11)The dopaminergic system has been the main focus for almost 70 years and dopaminergic-based strategies still remain the best symptomatic medication to improve quality of life of parkinsonian patients. -
Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects
; ; Rivero Calera, Guadalupe; ; ; ; ; Díez Alarcia, Rebeca ; ; ; Callado Hernando, Luis Felipe ; ; (Nature, 2024-02)
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu2R and mGlu3R) in brains of schizophrenia patients may explain the limited efficacy of mGlu2/3R ligands in clinical trials. ... -
Effects of adult enriched environment on cognition, hippocampal- prefrontal plasticity and NMDAR subunit expression in MK-801- induced schizophrenia model
; ; ; ; ; Lafuente Sánchez, José Vicente; (Elsevier, 2019-05-01)
Schizophrenia is a mental disorder characterized by psychosis, negative symptoms and cognitive impairment. Cognitive deficits are enduring and represent the most disabling symptom but are currently poorly treated. N-methyl ... -
Effects of galanin subchronic treatment on memory and muscarinic receptors.
; ; ; Manuel Vicente, Iván; Rodríguez Puertas, Rafael (Elsevier, 2015-05-07)
Las vías colinérgicas, que se originan en el prosencéfalo basal y son responsables del control de diferentes procesos cognitivos como el aprendizaje y la memoria también están reguladas por algunos neuropéptidos. Uno de ...