Listar Artículos, Comunicaciones, Libros por autor "Jaafar, Ali K."
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A Systematic Approach to Assess the Activity and Classification of PCSK9 Variants
Belloso Uribe, Kepa; Chemello, Kevin; Larrea Sebal, Asier; Benito Vicente, Asier; Bourane, Steeve; Jaafar, Ali K.; Lambert, Gilles; Martín Plágaro, César Augusto (MDPI, 2021-12-18)Background: Gain of function (GOF) mutations of PCSK9 cause autosomal dominant familial hypercholesterolemia as they reduce the abundance of LDL receptor (LDLR) more efficiently than wild-type PCSK9. In contrast, PCSK9 ...