Now showing items 1-20 of 224

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      1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

      Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier ORCID; Apraiz, A.; Arrizabalaga Uriarte, Oskar ORCID; Vellon, L.; Alberdi Alfonso, Elena María ORCID; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis ORCID (Nature Publishing Group, 2013-01)
      1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
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      18S rRNA V9 metabarcoding for diet characterization: a critical evaluation with two sympatric zooplanktivorous fish species 

      Albaina Vivanco, Aitor; Aguirre Rodrigo, Mikel ORCID; Abad García, David; Santos, María; Estomba Recalde, Miren Andone ORCID (Wiley Blackwell, 2016-03)
      The potential of the 18S rRNA V9 metabarcoding approach for diet assessment was explored using MiSeq paired-end (PE; 2 9 150 bp) technology. To critically evaluate the method's performance with degraded/digested DNA, the ...
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      A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression 

      Bonilla Ocampo, Diego A.; Moreno, Yurany; Petro, Jorge L.; Forero, Diego A.; Vargas-Molina, Salvador; Odriozola Martínez, Adrián; Orozco, Carlos A.; Stout, Jeffrey R.; Rawson, Eric S.; Kreider, Richard B. (MDPI, 2022-03-21)
      The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the ...
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      A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K 

      García Santisteban, Iraia ORCID; Arregi Vado, Igor; Alonso Mariño, Marian; Urbaneja Arrue, María Ángeles ORCID; García Vallejo, Juan J.; Bañuelos Rodríguez, Sonia ORCID; Rodríguez Pérez, José Antonio ORCID (Springer Nature Switzerland AG, 2016-12)
      The exportin CRM1 binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm. Structural and biochemical analyses have uncovered the molecular mechanisms ...
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      A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice 

      Prieto Fernández, Endika; Aransay Bañares, Ana María; Royo, Félix; González Jiménez, María Esperanza; Lozano, Juan José; Santos Zorrozúa, Borja ORCID; Macías Cámara, Nuria; González López, Monika; Pérez Garay, Raquel; Benito Fernández, Francisco Javier; García Orad, África; Falcón Pérez, Juan Manuel (Ivyspring International Publisher, 2019)
      Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ...
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      A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene 

      Ibarrola Villava, Maider; Fernandez, Lara P.; Alonso Alegre, Santos ORCID; Boyano López, María Dolores ORCID; Peña Chilet, María; Pita, Guillermo; Avilés, José A.; Mayor, Matias; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Izagirre Arribalzaga, Neskuts ORCID; De la Rúa Vaca, Concepción ORCID; Asumendi Mallea, Aintzane ORCID; Pérez-Yarza Pérez-Irezabal, Gorka ORCID; Arroyo Berdugo, Yoana; Boldo, Enrique; Lozoya, Rafael; Torrijos Aguilar, Arantxa; Pitarch, Ana; Pitarch, Gerard; Sánchez Motilla, José M.; Valcuende Cavero, Francisca; Tomás Cabedo, Gloria; Pérez Pastor, Gemma; Díaz Pérez, José Luis; Gardeazabal García, Jesús; Martínez de Lizarduy, Iñigo; Sánchez Díez, Ana; Valdés, Carlos; Pizarro, Angel; Casado, Mariano; Carretero, Gregorio; Botella Estrada, Rafael; Nagore, Eduardo; Lázaro, Pablo; Lluch, Ana; Benítez, Javier; Martínez Cadenas, Conrado; Ribas, Gloria (Public Library of Science, 2011-04-29)
      As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ...
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      A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family 

      García Santisteban, Iraia ORCID; Bañuelos Rodríguez, Sonia ORCID; Rodríguez Pérez, José Antonio ORCID (Portland Press LTD, 2012-01-01)
      The mechanisms that regulate the nucleocytoplasmic localization of human deubiquitinases remain largely unknown. The nuclear export receptor CRM1 binds to specific amino acid motifs termed NESs (nuclear export sequences). ...
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      A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells 

      González Moro, Itziar ORCID; Rojas Márquez, Henar; Sebastián de la Cruz, Maialen ORCID; Mentxaka Salgado, Jon; Olazagoitia Garmendia, Ane; Mendoza Gómez, Luis Manuel; Lluch, Aina; Fantuzzi, Federica; Lambert, Carmen; Ares Blanco, Jessica; Marselli, Lorella; Marchetti, Piero; Cnop, Miriam; Delgado, Elías; Fernández Real, José Manuel; Ortega, Francisco José; Castellanos Rubio, Ainara; Santín Gómez, Izortze (Frontiers Media, 2023-02)
      IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ...
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      A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health 

      Fernández Jiménez, Nora ORCID; Fore, Ruby; Cilleros Portet, Ariadna ORCID; Lepeule, Johanna; Perron, Patrice; Kvist, Tuomas; Tian, Fu-Ying; Lesseur, Corina; Binder, Alexandra M.; Lozano, Manuel; Martorell Marugán, Jordi; Loke, Yuk J.; Bakulski, Kelly M.; Zhu, Yihui; Forhan, Anne; Sammallahti, Sara; Everson, Todd M.; Chen, Jia; Michels, Karin B.; Belmonte, Thalia; Carmona Sáez, Pedro; Halliday, Jane; Fallin, M. Daniele; LaSalle, Janine M.; Tost, Jorg; Czamara, Darina; Fernández, Mariana F.; Gómez Martín, Antonio; Craig, Jeffrey M.; González Alzaga, Beatriz; Schmidt, Rebecca J.; Dou, John F.; Muggli, Evelyne; Lacasaña, Marina; Vrijheid, Martine; Marsit, Carmen J.; Karagas, Margaret R.; Raikkonen, Katri; Bouchard, Luigi; Heude, Barbara; Santa Marina Rodríguez, Loreto; Bustamante, Mariona; Hivert, Marie France; Bilbao Catalá, José Ramón ORCID (Nature, 2022-11)
      Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ ...
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      A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease 

      Sebastián de la Cruz, Maialen ORCID; Olazagoitia Garmendia, Ane; Huerta Madrigal, Alain; García Etxebarria, Koldo; Mendoza Gómez, Luis Manuel; Fernández Jiménez, Nora ORCID; García Casales, Zuriñe; De la Calle Navarro, E.; Calvo, A. E.; Legarda Tamara, María; Tutau Gómez, Carlos; Irastorza Epelde, Igor ORCID; Bujanda Fernández de Pierola, Luis ORCID; Bilbao Catalá, José Ramón ORCID; Castellanos Rubio, Ainara (Elsevier, 2021)
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      A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation 

      Castellanos Rubio, Ainara; Santín Gómez, Izortze; Olazagoitia Garmendia, Ane; Romero Garmendia, Irati; Jauregi Miguel, Amaia; Legarda, Maria; Bilbao Catalá, José Ramón ORCID (Nature Publishing Group, 2019-12)
      N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ...
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      A Novel Transcriptome-Derived SNPs Array for Tench (Tinca Tinca L.) 

      Kumar, Girish; Langa Arranz, Jorge Eliseo ORCID; Montes Asperilla, Iratxe ORCID; Conklin, Darrell; Kocour, Martin; Kohlmann, Klaus; Estomba Recalde, Miren Andone ORCID (Public Library Science, 2019-03-19)
      Tench (Tinca tinca L.) has great economic potential due to its high rate of fecundity and long-life span. Population genetic studies based on allozymes, microsatellites, PCR-RFLP and sequence analysis of genes and DNA ...
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      A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes 

      Ramírez Sánchez, Juan Manuel ORCID; Prieto Agujeta, Gorka ORCID; Olazabal Herrero, Ane; Borràs, Eva; Fernandez-Vigo, Elvira; Alduntzin Egizurain, Unai ORCID; Osinalde Moraleja, Nerea ORCID; Beaskoetxea Lejarzegi, Javier; Lectez, Benoît ORCID; Aloria Escolastico, Kerman; Rodríguez Pérez, José Antonio ORCID; Paradela, Alberto; Sabidó, Eduard; Muñoz, Javier; Corrales, Fernando; Arizmendi Bastarrika, Jesús María ORCID; Mayor Martínez, Ugo ORCID (MDPI, 2021-05-03)
      The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ...
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      A real-time PCR assay to estimate invertebrate and fish predation on anchovy eggs in the Bay of Biscay 

      Albaina Vivanco, Aitor; Irigoien, Xabier; Aldalur, Unai; Cotano, Unai; Santos, María; Boyra, Guillermo; Estomba Recalde, Miren Andone ORCID (Elsevier, 2014-12-12)
      In order to investigate the role of predation on eggs and larvae in the recruitment of anchovy (Engraulis encrasicolus), sardine (Sardina pilchardus), sprat (Sprattus sprattus) and 52 macrozooplankton taxa were assayed for ...
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      A Recording Form for Differential Diagnosis of Arthropathies 

      García Ventades, Nerea ORCID; Martín Laza, Imanol ORCID; Hervella Afonso, Montserrat ORCID; De la Rúa Vaca, Concepción ORCID (Elsevier, 2018-03)
      The present study is focused on a group of arthropathies that may have very similar bone manifestations (rheumatoid arthritis, ankylosing spondylitis, reactive arthritis, psoriatic arthritis, osteoarthritis and diffuse ...
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      A short exposure to a semi-natural habitat alleviates the honey bee hive microbial imbalance caused by agricultural stress 

      Gorrochategui Ortega, June; Muñoz Colmenero, Marta; Kovačić, Marin; Filipi, Janja; Puškadija, Zlatko; Kezić, Nikola; Parejo Feuz, Melanie; Büchler, Ralph; Estomba Recalde, Miren Andone ORCID; Zarraonaindia Martínez, Iratxe ORCID (Nature, 2022-11)
      Honeybee health and the species' gut microbiota are interconnected. Also noteworthy are the multiple niches present within hives, each with distinct microbiotas and all coexisting, which we termed "apibiome". External ...
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      A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis 

      Sarasola, Esther; Rodríguez Pérez, José Antonio ORCID; Garrote Llanos, María Isabel; Arístegui Fernández, Javier; García-Barcina, María J. (BioMed Central, 2011-06-27)
      Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis. It is caused by mutations in the ...
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      A statistical investigation into the sharing of common genetic factors between blood pressure and obesity phenotypes in nuclear families from the Greater Bilbao (Spain) 

      Jelenkovic Moreno, Aline; Poveda Zabala, Alaitz; Rebato Ochoa, Esther Matilde ORCID (Lippincott, Williams & Wilkins, 2010)
      Objectives: Several obesity phenotypes (e.g. body mass and fat, fat distribution) have been suggested to be a risk for elevated blood pressure. This study was undertaken to determine the heritability of four blood pressure ...
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      A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia 

      López López, Elixabet; Martín Guerrero, Idoia; Ballesteros Rodríguez, Francisco Javier ORCID; García-Orad Carles, África (Springer, 2013-10-23)
      Methotrexate (MTX) is an important component of therapy used to treat childhood acute lymphoblastic leukemia (ALL). Two single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T ...
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      A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes 

      Garitazelaia González, Aiara; Rueda Martínez, Aintzane; Arauzo, Rebeca; De Miguel, Jokin; Cilleros Portet, Ariadna ORCID; Marí Alemany, Sergi; Bilbao Catalá, José Ramón ORCID; Fernández Jiménez, Nora ORCID; García Santisteban, Iraia ORCID (MDPI, 2021-01-03)
      Endometriosis, one of the most common gynecological disorders, is a complex disease characterized by the growth of endometrial-like tissue in extra-uterine locations and is a cause of pelvic pain and infertility. Evidence ...