BackExaminar Artículos, Comunicaciones, Libros por departamento (cas.) "Química orgánica I"
Now showing items 1-20 of 168
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1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis
Mielgo Vicente, María Antonia
; (Beilstein Institut, 2016-05-09)
Asymmetric catalysis represents a very powerful tool for the synthesis of enantiopure compounds. In this context the main focus has been directed not only to the search for new efficient chiral catalysts, but also to the ... -
5-Ethoxy-1-(4-methoxyphenyl)-5-methyl-3-phenylimidazolidine-2,4-dione
; ; Martínez de Marigorta Izaga, Edorta; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2021-05-28)
The title compound is a hydantoin derivative that has been synthesized through a three-component reaction of ethyl pyruvate, p-anisidine and phenyl isocyanate. This paper provides a comprehensive spectral dataset for the ... -
A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives
; Martínez de Marigorta Izaga, Edorta; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2019-08)
Bronsted acids catalyze a multicomponent reaction of benzaldehyde with amines and diethyl acetylenedicarboxylate to afford highly functionalized gamma-lactam derivatives. The reaction consists of a Mannich reaction of an ... -
A Call for a Change in Policy Regarding the Necessity for SDE Tests to Validate the Veracity of the Outcome of Enantioselective Syntheses, the Inherent Chiral State of Natural Products, and Other Cases Involving Enantioenriched Samples
Han, Jianlin; Dembinski, Roman; Soloshonok, Vadym Anatolievch ; Klika, Karel D. (MDPI, 2021-06-30)
We wish to draw attention to an important issue concerning scientific practice with regard to enhancing the quality of publications in <i>Molecules</i> (as well as for other journals) [...] -
A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors
; ; ; ; Palacios Gambra, Francisco Javier; Alonso Pérez, Concepción Estibaliz ; ; (MDPI, 2021-07-15)
DNA sensors can be used as robust tools for high-throughput drug screening of small molecules with the potential to inhibit specific enzymes. As enzymes work in complex biological pathways, it is important to screen for ... -
A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents
; ; ; ; ; Martínez de Marigorta Izaga, Edorta; Pedraz Muñoz, José Luis ; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2021-08-09)
An efficient synthetic methodology for the preparation of 3-amino 1,5-dihydro-2H-pyrrol-2-ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is reported. In addition, the densely substituted ... -
Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
(American Chemical Society, 2022-12)The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon–carbon bond forming reactions. The ... -
Additive and Emergent Catalytic Properties of Dimeric Unnatural Amino Acid Derivatives: Aldol and Conjugate Additions.
; ; ; ; ; Cossío Mora, Fernando Pedro (Wiley, 2021-11-11)
[EN]Different densely substituted L- and D-proline esters were prepared by asymmetric (3+2) cycloaddition reactions catalyzed by conveniently selected EhuPhos chiral ligands. The gamma-nitro-2-alkoxycarbonyl pyrrolidines ... -
Advances in the Development of Trifluoromethoxylation Reagents
Wang, Qian; Zhang, Xin; Sorochinsky, Alexander E.; Butler, Greg; Han, Jianlin; Soloshonok, Vadym Anatolievch (MDPI, 2021-12-10)
This review provides a short summary of the traditional methods for synthesis of CF3-O-containing compounds, followed by a critical overview of known trifluoromethoxylating reagents, focusing on their preparation, synthetic ... -
Alkene selenenylation: A comprehensive analysis of relative reactivities, stereochemistry and asymmetric induction, and their comparisons with sulfenylation
Soloshonok, Vadym Anatolievch; Nelson, Donna J. (Beilstein Institut, 2011-06)
A broad perspective of various factors influencing alkene selenenylation has been developed by concurrent detailed analysis of key experimental and theoretical data, such as asymmetric induction, stereochemistry, relative ... -
alpha-Branched Ketone Dienolates: Base-Catalyzed Generation and Regio- and Enantioselective Addition Reactions
; ; ; ; ; Oyarbide Garmendia, Juan Miguel; (Wiley-VCH, 2019-05-14)
In this study, the unique capacity of bifunctional Brønsted bases to generate α-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon ... -
An Expedient Method for the Umpolung Coupling of Enols with Heteronucleophiles
; Carretero Cerdán, Alba; Sanz-Marco, Amparo ; ; (Wiley, 2022-08)
[EN] In this paper, we present an unprecedented and general umpolung protocol that allows the functionalization of silyl enol ethers and of 1,3-dicarbonyl compounds with a large range of heteroatom nucleophiles, including ... -
An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C=O and C=N bonds
; Martínez de Marigorta Izaga, Edorta; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier ; (RSC, 2022-09-07)
Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first examples were reported 18 years ago by Akiyama and Terada. Although they were originally developed for enantioselective additions ... -
An umpolung strategy to react catalytic enols with nucleophiles
(Nature, 2019-11-20)The selective synthesis of a-functionalized ketones with two similar enolizable positions can be accomplished using allylic alcohols and iridium(III) catalysts. A formal 1,3-hydrogen shift on allylic alcohols generates ... -
Antileishmanial Effect of 1,5- and 1,8-Substituted Fused Naphthyridines
; ; Palacios Gambra, Francisco Javier; ; ; ; ; Alonso Pérez, Concepción Estibaliz ; (MDPI, 2023-12-22)
In the absence of a vaccine, there is a need to find new drugs for the treatment of neglected tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those currently used. These disadvantages ... -
Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases
Arriortua, Oihane; ; Herrero de la Parte, Borja ; ; ; Plazaola Muguruza, Fernando ; ; Aizpurua Iparraguirre, Jesús María ; ; ; ; García-Alonso Montoya, Ignacio ; ; (Beilstein-Institut, 2016-10-28)
This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could ... -
Application of 1,3-Dipolar Reactions between Azomethine Ylides and Alkenes to the Synthesis of Catalysts and Biologically Active Compounds
; Arrieta Ayestaran, Ana Jesús; Cossío Mora, Fernando Pedro (Wiley, 2018-11-25)
The (3+2) cycloaddition between azomethine ylides and alkenes is an efficient, convergent and stereocontrolled method for the synthesis of unnatural pyrrolidine and proline scaffolds. In this review, the application of ... -
Aromaticity: Quo Vadis
; ; ; ; ; ; ; ; Cossío Mora, Fernando Pedro; ; ; ; (Royal Society of Chemistry, 2023)
Aromaticity is one of the most deeply rooted concepts in chemistry. But why, if two-thirds of existing compounds can be classified as aromatic, is there no consensus on what aromaticity is? s−, p−, d−, spherical, Möbius, ... -
Asymmetric Mannich reactions of (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimines with yne nucleophiles
Li, Ziyi; Wang, Li; Huang, Yunqi; Mei, Haibo; Konno, Hiroyuki; Moriwaki, Hiroki; Soloshonok, Vadym Anatolievch; Han, Jianlin (Beilstein-Institut, 2020-10-29)
In the present work, arylethynes were studied as new C-nucleophiles in the asymmetric Mannich addition reactions with (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. The reactions were conducted under operationally ... -
Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
Han, Jianlin; ; Fustero, Santos ; ; Soloshonok, Vadym Anatolievch ; Sorochinsky, Alexander (MDPI, 2022)
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, ...