BackBrowsing Artículos, Comunicaciones, Libros by Subject "MOLECULAR BIOLOGY"
Now showing items 1-18 of 18
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A Minimal Model of Metabolism-Based Chemotaxis
Egbert, Matthew D.; Barandiaran Fernández, Xabier Eugenio
; Di Paolo, Ezequiel (Public Library of Science, 2010-12-02)
Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption. Recent ... -
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model : mechanism for deficient glutamatergic transmission?
(BioMed Central, 2011-07-30)Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal ... -
Biomolecule storage on non-modified thermoplastic microfluidic chip by ink-jet printing of ionogels
Tijero, María; Díez Ahedo, Ruth; Benito López, Fernando; Basabe Desmonts, Lourdes ; Castro López, Vanessa; Valero, Ana (American Institute of Physics (AIP), 2015)
[EN] This paper reports an innovative technique for reagents storage in microfluidic devices by means of a one-step UV-photoprintable ionogel-based microarray on non-modified polymeric substrates. Although the ionogel and ... -
Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS
(Biomed Central, 2015-08-01)Background: There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through ... -
Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering
Ibarretxe Bilbao, Gaskon; Álvarez Díaz, Antonia Ángeles; Cañavate Escribano, María Luz; ; Aurrekoetxea Campo, Maitane; Unda Rodríguez, Fernando José (SAGE-Hindawi Access to Research, 2012-03-29)
The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected ... -
Composition and conservation of the mRNA-degrading machinery in bacteria
(BioMed Central, 2011)RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data ... -
Conformational Sampling and Nucleotide-Dependent Transitions of the GroEL Subunit Probed by Unbiased Molecular Dynamics Simulations
; Grant, Barry; Muga Villate, Arturo; Teigen, Knut; McCammon, J. Andrew; Reuter, Nathalie; Martínez, Aurora (Public Library of Science, 2011-03-10)
GroEL is an ATP dependent molecular chaperone that promotes the folding of a large number of substrate proteins in E. coli. Large-scale conformational transitions occurring during the reaction cycle have been characterized ... -
Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis
Delgado San Vicente, Diego; Del Pozo Rodríguez, Ana; Solinís Aspiazu, María Ángeles ; Avilés Triqueros, Marcelino; Weber, Bernhard H.F.; Fernández, Eduardo; (Mary Ann Liebert, Inc., 2012-04)
[EN]The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile ... -
HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
(Public Library Science, 2014-07)Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism ... -
ICGE: an R package for detecting relevant clusters and atypical units in gene expression
Irigoyen Garbizu, Itziar; Sierra Araujo, Basilio; Arenas Solá, Concepción (BioMed Central, 2012-02)
Background: Gene expression technologies have opened up new ways to diagnose and treat cancer and other diseases. Clustering algorithms are a useful approach with which to analyze genome expression data. They attempt to ... -
Insights into mechanism kinematics for protein motion simulation
; Petuya Arcocha, Víctor; Martínez Cruz, Luis Alfonso; Hernández Frías, Alfonso (Biomed Central, 2014-06-12)
Background: The high demanding computational requirements necessary to carry out protein motion simulations make it difficult to obtain information related to protein motion. On the one hand, molecular dynamics simulation ... -
Ionic Liquids and Cellulose: Dissolution, Chemical Modification and Preparation of New Cellulosic Materials
Isik, Mehmet; ; (MDPI, 2014-07)
Due to its abundance and a wide range of beneficial physical and chemical properties, cellulose has become very popular in order to produce materials for various applications. This review summarizes the recent advances in ... -
Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia
Alonso Alconada, Daniel; Álvarez Díaz, Antonia Ángeles; ; ; (MDPI AG, 2013-04-29)
One of the most common causes of mortality and morbidity in children is perinatal hypoxia-ischemia (HI). In spite of the advances in neonatology, its incidence is not diminishing, generating a pediatric population that ... -
Noisy-threshold control of cell death
(BioMed Central, 2010)Background Cellular responses to death-promoting stimuli typically proceed through a differentiated multistage process, involving a lag phase, extensive death, and potential adaptation. Deregulation of this chain of events ... -
PAnalyzer: A software tool for protein inference in shotgun proteomics
Prieto Agujeta, Gorka; Aloria Escolastico, Kerman; Osinalde Moraleja, Nerea ; Fullaondo Elordui-Zapaterieche, Asier ; Arizmendi Bastarrika, Jesús María ; Matthiesen, Rune (BioMed Central, 2012-11-05)
Background Protein inference from peptide identifications in shotgun proteomics must deal with ambiguities that arise due to the presence of peptides shared between different proteins, which is common in higher eukaryotes. ... -
Prediction of Multi-Target Networks of Neuroprotective Compounds with Entropy Indices and Synthesis, Assay, and Theoretical Study of New Asymmetric 1,2-Rasagiline Carbamates
(MDPI, 2014-09)In a multi-target complex network, the links (L-ij) represent the interactions between the drug (d(i)) and the target (t(j)), characterized by different experimental measures (K-i, K-m, IC50, etc.) obtained in pharmacological ... -
Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus
(Public Library of Science, 2013-01-03)The biosynthesis of membrane lipids is an essential pathway for virtually all bacteria. Despite its potential importance for the development of novel antibiotics, little is known about the underlying signaling mechanisms ... -
The promoter of cell growth- and RNA protection-associated SND1 gene is activated by endoplasmic reticulum stress in human hepatoma cells
Armengol López, Sandra; Artetxe, Enara; Enzunza, Leire; Mula, Sarai; ; Chico Carmona, Yolanda; Martínez San Pelayo, María José (Biomed Central, 2014-12-11)
Background: Staphyloccocal nuclease domain-containing protein 1 (SND1) is involved in the regulation of gene expression and RNA protection. While numerous studies have established that SND1 protein expression is modulated ...