BackBrowsing Artículos, Comunicaciones, Libros by Subject "MOLECULAR MEDICINE"
Now showing items 1-7 of 7
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Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis
Delgado San Vicente, Diego; Del Pozo Rodríguez, Ana
; Solinís Aspiazu, María Ángeles ; Avilés Triqueros, Marcelino; Weber, Bernhard H.F.; Fernández, Eduardo; (Mary Ann Liebert, Inc., 2012-04)
[EN]The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile ... -
Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain
De Gunst, Matheus M.; Gallegos Ruiz, Marielle I.; Giaccone, Giuseppe; Rodríguez Pérez, José Antonio (BioMed Central, 2007-09)
Background: The presence of EGFR kinase domain mutations in a subset of NSCLC patients correlates with the response to treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Although most EGFR mutations ... -
MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
Umerez, Maitane; Gutiérrez Camino, Ángela; Muñoz Maldonado, Carmen; ; García-Orad Carles, África (Dove Medical Press, 2017-03-27)
Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ... -
RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation
Morales, Mónica; Arenas, Enrique J.; Urosevic, Jelena; Guiu, Marc; Fernández, Esther; Planet, Evarist; Fenwick, Robert Bryn; Fernández-Ruiz, Sonia; Salvatella, Xavier; Reverter, David; Carracedo Pérez, Arkaitz; Massagué, Joan; Gomis, Roger R (Wiley Blackwell, 2014-07)
In estrogen receptor-negative breast cancer patients, metastatic relapse usually occurs in the lung and is responsible for the fatal outcome of the disease. Thus, a better understanding of the biology of metastasis is ... -
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage
Olazabal Herrero, Ane; García Santisteban, Iraia; Rodríguez Pérez, José Antonio (Biomed Central, 2015-02-06)
Background: In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel ... -
Uptake and intracytoplasmic storage of pigmented particles by human CD34+stromal cells/telocytes: endocytic property of telocytes
Díaz-Flores, Lucio; Gutiérrez, Ricardo; García, María Pino; Sáez Crespo, Francisco José; Aparicio, Fernando; Díaz-Flores Jr, Lucio; Madrid, Juan F. (Wiley Blackwell, 2014-12)
We studied the phagocytic-like capacity of human CD34+ stromal cells/telocytes (TCs). For this, we examined segments of the colon after injection of India ink to help surgeons localize lesions identified at endoscopy. Our ... -
USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy
García Santisteban, Iraia; Peters, Godefridus J.; Giovannetti, Elisa; Rodríguez Pérez, José Antonio (Biomed Central, 2013)
Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs), are increasingly ...