BackBrowsing Artículos, Comunicaciones, Libros by Subject "ONCOLOGY"
Now showing items 1-19 of 19
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Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy
(Nature Publishing Group, 2014-05)Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be ... -
Altered glutamyl-aminopeptidase activity and expression in renal neoplasms
; ; Pérez Urzelai, Itxaro
; ; ; ; Gil Goicouría, Francisco Javier ; ; López Fernández de Villaverde, José Ignacio ; Larrinaga Embeita, Gorka (Biomed Central, 2014-05-30)
Background: Advances in the knowledge of renal neoplasms have demonstrated the implication of several proteases in their genesis, growth and dissemination. Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase ... -
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels
Ruiz Núñez, Asier; Alberdi Alfonso, Elena María ; (Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ... -
Differential activity of GSK-3 isoforms regulates NF-kappa B and TRAIL- or TNF alpha induced apoptosis in pancreatic cancer cells
Zhang, J.S.; Herreros Villanueva, Marta; Koenig, A.; Deng, Z.; M De Narvajas, A. A.; Gómez, T. S.; Meng, X.; Bujanda Fernández de Pierola, Luis; Ellenrieder, V.; Li, X. K.; Kaufmann, S. H.; Billadeau, D. D. (Nature Publishing Group, 2014-03)
While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting ... -
DNA methylation epigenotypes in breast cancer molecular subtypes
García Bediaga, Naiara; Acha Sagredo, Amelia; Guerra, Isabel; Viguri, Amparo; Albaina, Carmen; Ruiz Díaz, Irune; Rezola, Ricardo; Alberdi, María Jesús; Dopazo, Joaquín; Montaner, David; Renobales Scheifler, María Mercedes de; Fernández Fernández, Agustín; Field, John K.; Fraga, Mario F.; Liloglou, Liloglou; Martínez de Pancorbo Gómez, María de los Angeles (BioMed Central, 2010-09-29)
Introduction: Identification of gene expression-based breast cancer subtypes is considered a critical means of prognostication. Genetic mutations along with epigenetic alterations contribute to gene-expression changes ... -
Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells
Apraiz García, Aintzane; Idkowiak-Baldys, Jolanta K.; Boyano López, María Dolores ; Pérez-Yarza Pérez-Irezabal, Gorka ; ; Asumendi Mallea, Aintzane (BioMed Central, 2011-10-07)
Background -- N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a synthetic retinoid with potent pro-apoptotic activity against several types of cancer, but little is known regarding mechanisms leading to chemoresistance. ... -
Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent
; ; ; Gil Goicouría, Francisco Javier; Irazusta Astiazaran, Jon ; López Fernández de Villaverde, José Ignacio ; ; ; Larrinaga Embeita, Gorka (BioMed Central, 2010-05)
Background: Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP ... -
Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain
De Gunst, Matheus M.; Gallegos Ruiz, Marielle I.; Giaccone, Giuseppe; Rodríguez Pérez, José Antonio (BioMed Central, 2007-09)
Background: The presence of EGFR kinase domain mutations in a subset of NSCLC patients correlates with the response to treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Although most EGFR mutations ... -
Identification of a biomarker panel for colorectal cancer diagnosis
García Bilbao, Amaia; Armañanzas Arnedillo, Rubén; Ispizua, Ziortza; Calvo Hernaez, Begoña; ; Inza Cano, Iñaki; Larrañaga, Pedro; López Vivanco, Guillermo María; Suárez Merino, Blanca; Betanzos, Mónica (BioMed Central, 2012-01-26)
Background: Malignancies arising in the large bowel cause the second largest number of deaths from cancer in the Western World. Despite progresses made during the last decades, colorectal cancer remains one of the most ... -
Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease
(Nature Publishing Group, 2010-01)The formation of cerebral senile plaques composed of amyloid beta peptide (A beta) is a fundamental feature of Alzheimer's disease (AD). Glial cells and more specifically microglia become reactive in the presence of A beta. ... -
Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes
Ruiz Núñez, Asier; ; Alberdi Alfonso, Elena María (Nature Publishing Group, 2010-07)
Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ... -
Is there a subgroup of long-term evolution among patients with advanced lung cancer?: Hints from the analysis of survival curves from cancer registry data
Sánchez, Lizet; Lorenzo-Luaces, Patricia; Viada, Carmen; Galán, Yaima; Ballesteros Rodríguez, Francisco Javier; Crombet, Tania; Lage, Agustín (Biomed Central, 2014-12-11)
Background: Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected ... -
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; (Nature Publishing Group, 2012-02)
We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ... -
Pravastatin inhibits cell proliferation and increased MAT1A expression in hepatocarcinoma cells and in vivo models
Hijona Muruamendiaraz, Elizabeth; Bañales Asurmendi, Jesús María; Hijona Muruamendiaraz, Lander; Medina, Juan F.; Arenas Mirave, Juan Ignacio; Herreros Villanueva, Marta; Aldazabal, Pablo; Bujanda Fernández de Pierola, Luis (BioMed Central, 2012-02-21)
Background: Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeutic ... -
Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia
Aguirre Urizar, José Manuel (BioMed Central, 2011-10)
In this letter I propose the name "Proliferative Multifocal Leukoplakia" with the goal of reducing under-diagnosis of this disease, improve the early diagnosis, try to make an early therapy and control, and prevent its ... -
Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial
Solomón, María Teresa; Selva, Julio César; Figueredo, Javier; Vaquer, José; Toledo, Carolina; Quintanal, Nelson; Salva, Silvia; Domínguez, Rafael; Alert, José; Marinello, Jorge Juan; Catalá, Mauricio; González Griego, Martha; Martell, Juan Antonio; Lorenzo Luaces, Patricia; Ballesteros Rodríguez, Francisco Javier; De Castro, Niurys; Bach, Ferdinand; Crombet, Tania (BioMed Central, 2013-06-19)
Background The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a ... -
Snail heterogeneity in clear cell renal cell carcinoma
(Biomed Central, 2016-03-08)Background: Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, ... -
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage
Olazabal Herrero, Ane; García Santisteban, Iraia; Rodríguez Pérez, José Antonio (Biomed Central, 2015-02-06)
Background: In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel ... -
USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy
García Santisteban, Iraia; Peters, Godefridus J.; Giovannetti, Elisa; Rodríguez Pérez, José Antonio (Biomed Central, 2013)
Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs), are increasingly ...