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Amide-Directed Intramolecular Co(III)-Catalyzed C-H Hydroarylation of Alkenes for the Synthesis of Dihydrobenzofurans with a Quaternary Center
(American Chemical Society, 2020-07-17)
The first example of Cp*Co(III)-catalyzed intramolecular hydroarylation of allyl aryl ethers using an amide directing group for the preparation of 3,3-disubstituted dihydrobenzofurans in high yields is described. The ...
Chiral Bronsted Acid-Catalyzed Enantioselective alpha-Amidoalkylation Reactions: A Joint Experimental and Predictive Study,
(Wiley VCH, 2016-12)
Enamides with a free NH group have been evaluated as nucleophiles in chiral Bronsted acid-catalyzed enantioselective alpha-amidoalkylation reactions of bicyclic hydroxylactams for the generation of quaternary stereocenters. ...
Microwave-assisted Palladium catalysed C-H acylation with aldehydes. Synthesis and diversification of 3-acylthiophenes
(Royal Society of Chemistry, 2021-12-22)
The use of MW allows the efficient palladium(II)-catalysed C-3 acylation of thiophenes with aldehydes via C(sp2)-H activation for the synthesis of (cyclo)alkyl/aryl thienyl ketones (43 examples). Compared to standard thermal ...
Palladium-catalysed Heck-type alkenylation reactions in the synthesis of quinolines. Mechanistic insights and recent applications
(Royal Society of Chemistry, 2020-05-18)
Quinoline and quinolone cores are present in a wide variety of pharmaceuticals, agrochemicals and materials, as well in ligands/catalysts in asymmetric synthesis. Transition-metal catalysed based approaches have played a ...
Selective Pd(II)-catalyzed Acylation of Pyrrole with Aldehydes. Application to the Synthesis of Celastramycin analogues and Tolmetin
(Wiley-VCH, 2020-04-27)
The Pd(II)-catalyzed C-2 acylation of pyrrole with aldehydes in the presence of TBHP as oxidant has been studied for the synthesis of di(hetero)aryl ketones. The use of 2-pyrimidine as directing group leads to 2-acylpyrroles ...
Prediction of Antileishmanial Compounds: General Model, Preparation, and Evaluation of 2‑Acylpyrrole Derivatives
(ACS, 2022-08-10)
In this work, the SOFT.PTML tool has been used to pre-process a
ChEMBL dataset of pre-clinical assays of antileishmanial compound candidates.
A comparative study of different ML algorithms, such as logistic regression
(LOGR), ...
Directed C- H Allylation of Aromatic Carboxamides with Allyl Aryl Ethers under Cp*Co(III)-Catalysis
(Wiley-VCH, 2023-11-20)
The Cp*Co(III) C−H allylation of (hetero)arenes with allyl aryl ethers has been developed using an amide as directing group (24 examples). DFT calculations have shed light on the mechanistic course and reactivity pattern, ...
Cp*Co(III)-Catalyzed C−H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool
(ACS, 2020-09-15)
The use of earth-abundant first-row transition
metals, such as cobalt, in C−H activation reactions for the
construction and functionalization of a wide variety of structures
has become a central topic in synthetic ...
Palladium-mediated synthesis and biological evaluation of C-10b substituted Dihydropyrrolo[1,2-b]isoquinolines as antileishmanial agents
(Elsevier, 2021-04-16)
The development of new molecules for the treatment of leishmaniasis is, a neglected parasitic disease, is
urgent as current anti-leishmanial therapeutics are hampered by drug toxicity and resistance. The pyrrolo[
1,2-b ...
Phenolic Activation in Chiral Brønsted Acid-Catalyzed Intramolecular α‑Amidoalkylation Reactions for the Synthesis of Fused Isoquinolines
(ACS, 2017-06-16)
An organolithium addition−intramolecular α-
amidoalkylation sequence on N-phenethylimides has been
developed for the synthesis of fused tetrahydroisoquinoline
systems using 1,1′-bi-2-naphthol (binol)-derived Brønsted
acids. ...