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Now showing items 41-47 of 47
Attachment anxiety as mediator of the relationship between childhood trauma and personality dysfunction in borderline personality disorder
(Wiley, 2022-03)
Insecure attachment has been described as mediating the relationship between childhood trauma and dysfunctional personality traits in different mental disorders. Despite the role insecure attachment and childhood trauma ...
Clemastine Induces an Impairment in Developmental Myelination
(Frontiers Media, 2022)
[EN] Abnormalities in myelination are associated to behavioral and cognitive dysfunction in neurodevelopmental psychiatric disorders. Thus, therapies to promote or accelerate myelination could potentially ameliorate symptoms ...
Senescence plays a role in myotonic dystrophy type 1 br
(American Society for Clinical Investigation, 2022-10)
Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 ...
A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease
(Frontiers Media, 2022-04-14)
Glial cells are essential to understand Alzheimer's disease (AD) progression, given their role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to manipulate models that allow studying the ...
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
(Frontiers Media, 2022-10-18)
The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ...
A validated WAIS-IV short-form to estimate intellectual functioning in myotonic dystrophy type 1
(Elsevier, 2022-09)
Currently, no rapid and specific instrument is available to briefly estimate intelligence in patients with myotonic dystrophy type 1 (DM1), a multisystemic disease that involves the CNS and is associated with cognitive ...
Plasma and serum alpha-synuclein as a biomarker in Parkinson's disease: A meta-analysis
(Elsevier, 2022-06)
Background
Reliable biomarkers for Parkinson's disease (PD) diagnosis are urgently needed. Alpha-synuclein (α-syn) and its proteoforms play a key role in PD pathology but in vivo measurements have raised conflicting ...